Fig. 1

Effect of paclitaxel on mechanical allodynia in rats. Rats were administrated intraperitoneally at dose of 2 mg/kg paclitaxel or vehicle on days 0, 2, 4 and 6. The paw withdrawal threshold (PWT) to a static mechanical stimulus was assessed using a von Frey anesthesiometer. PWT was measured pre-injection (baseline) and on days 7, 14 and 21 after first paclitaxel administration. All data are expressed as mean ± SEM (n = 5/group/time point). *P < 0.05 versus baseline under the same treatment; ^# P < 0.05, ^## P < 0.01 versus paclitaxel group