Long noncoding RNA MALAT1 can serve as a valuable biomarker for prognosis and lymph node metastasis in various cancers: a meta-analysis

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Table 1 The main characteristics of the included studies in the meta-analysis

First author	Year	Region	Ethnicity	Tumor type	Sample size	Cut-off value	Follow-up (months)	Detection method	Survival analysis		Outcome
Ji P	2003	Germany	Caucasian	NSCLC	225	Median	60 (total)	qRT-PCR	N/A		OS
Schmidt LH	2011	Germany	Caucasian	NSCLC	352	N/A	N/A	ISH	Univariate		OS
Lai MC	2012	China	Asian	HCC	164	Mean	36 (total)	qRT-PCR	Univariate	Multivariate	RFS
Okugawa Y	2014	Japan	Asian	GC	150	ROC	60 (total)	qRT-PCR	Univariate	Multivariate	OS
Liu JH	2014	China	Asian	PDAC	45	ROC	47 (total)	qRT-PCR	Univariate	Multivariate	DSS
Zheng HT	2014	China	Asian	CRC	146	Median	60(total)	qRT-PCR	Univariate	Multivariate	OS, DFS
Zhang HM	2014	China	Asian	ccRCC	106	Mean	60 (total)	qRT-PCR	Univariate	Multivariate	OS
Fan Y	2014	China	Asian	Bladder cancer	95	Median	30 (total)	qRT-PCR	Multivariate		OS
Pang EJ	2015	China	Asian	PDAC	126	Median	60 (total)	qRT-PCR	Univariate	Multivariate	OS
Hu L	2015	China	Asian	EC	54	Mean	N/A	qRT-PCR	N/A		N/A
Ma KX	2015	China	Asian	Glioma	118	Median	60 (total)	qRT-PCR	Univariate	Multivariate	OS
Hirata H	2015	Japan	Asian	ccRCC	50	Median	60 (total)	qRT-PCR	Univariate	Multivariate	OS
Dong YQ	2015	China	Asian	Osteosarcoma	19	Mean	60 (total)	qRT-PCR	N/A		OS
Huang CX	2016	China	Asian	EC	132	Mean	60 (total)	qRT-PCR	Multivariate		OS
Huang NS	2016	China	Asian	Breast cancer	204	75 %	65(median)	qRT-PCR	Multivariate		RFS
Wang SH	2016	China	Asian	GBC	30	Median	40 (total)	qRT-PCR	N/A		OS
Miao YF	2016	China	Asian	Breast cancer	78	Median	60 (total)	qRT-PCR	N/A		DFS

NSCLC non-small cell lung cancer, HCC hepatocellular carcinoma, GC gastric cancer, PDAC pancreatic ductal adenocarcinoma, CRC colorectal cancer, ccRCC clear cell renal cell carcinoma, EC esophageal cancer, GBC gallbladder cancer, N/A not available, qRT-PCR quantitative real-time PCR, OS overall survival, RFS recurrence-free survival, DSS disease specific survival, DFS disease-free survival