Cardiac and testicular toxicity effects of the latex and ethanolic leaf extract of Calotropis procera on male albino rats in comparison to abamectin

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Table 3 Effect of latex and ethanolic leaf extract and abamectin on serum testosterone, FSH and LH levels in normal rats

Treatments	Parameter
	Testosterone (ng/ml)		FSH (mlU/ml)		LH (mlU/ml)
	4 weeks	8 weeks	4 weeks	8 weeks	4 weeks	8 weeks
Vehicle (CMC1 %) control	2.71 ± 0.28^a	2.22 ± 0.35^a	0.26 ± 0.01^a	0.23 ± 0.01^abc	0.19 ± 0.01^a	0.17 ± 0.01^abcd
1/20 LD₅₀ latex	1.21 ± 0.11^bcd	1.1 ± 0.16^bcd	0.25 ± 0.01^a	0.20 ± 0.01^defg	0.18 ± 0.01^ab	0.14 ± 0.01^fg
1/10 LD₅₀ latex	0.75 ± 0.13^d	0.84 ± 0.04^cd	0.19 ± 0.01^efg	0.18 ± 0.01^fg	0.15 ± 0.01^efg	0.14 ± 0.01^g
1/20 LD₅₀ ethanolic extract	1.63 ± 0.21^b	1.38 ± 0.36^bc	0.23 ± 0.01^abcd	0.21 ± 0.01^cdef	0.16 ± 0.01^cdef	0.16 ± 0.01^bcde
1/10 LD₅₀ ethanolic extract	1.19 ± 0.06^bcd	0.88 ± 0.16^cd	0.20 ± 0.01^efg	0.19 ± 0.02^efg	0.16 ± 0.01^def	0.14 ± 0.01^efg
1/20 LD50 ABM	1.02 ± 0.15^cd	0.81 ± 0.11^d	0.25 ± 0.01^abc	0.22 ± 0.01^bcde	0.18 ± 0.01^ab	0.18 ± 0.01^abc
1/10 LD50 ABM	0.88 ± 0.07^cd	0.68 ± 0.06^d	0.24 ± 0.02^ab	0.18 ± 0.02^g	0.16 ± 0.01^cdef	0.15 ± 0.01^efg
F-probability	P < 0.001		P < 0.001		P < 0.001
LSD at 5 % level	0.5479		0.0311		0.0199
LSD at 1 % level	0.7379		0.0419		0.0269

Data are expressed as mean ± SE
Number of animals in each group is six
For each parameter, means, which do not share the same superscript symbol(s), are significantly different at P < 0.05