From: Triclosan in water, implications for human and environmental health
Cell type | TCS Concentration (µM) | Exposure (h) | Toxicity | References |
---|---|---|---|---|
Human breast cancer cells MCF-7 | ≥345.4 | 120 | Proliferation (oestrogenicity) | Henry and Fair (2013) |
Human (A549) lung cancer cell | 250 | 24 | Cell membrane damage (LDH release) | Kwon et al. (2013) |
Human (H460) lung cancer cell | 10 | 24 | Apoptotic and proliferative effect, Cell membrane damage (LDH release) | Winitthana et al. (2014) |
Human PBMC | ≥8.6 | 30 | Loss of mitochondrial transmembrane potential; metabolic acidosis; uncoupling of oxidative phosphorylation | Ajao et al. (2015) |
Human keratinocytes HaCaT | ≥8.6 | 30 | Loss of mitochondrial transmembrane potential; necrosis | Ajao et al. (2015) |
Rat fibroblast cells (RBL) | ≥5 | 1 | Uncoupling of mitochondrial oxidative phosphorylation | Weatherly et al. (2016) |
Human mast cells (HMC-1.2) | ≥5 | 1 | ||
Mouse JB6 Cl 41-5a cells | ≥8 | ≥48 | Decreased growth; cell damage (increased LDH release); necrosis | Wu et al. (2015) |
Zebrafish (Danio rerio, AB strain) embryos | 15 | 1 | Uncoupling of mitochondrial oxidative phosphorylation | Shim et al. (2016) |
Freshwater Protozoan (Tetrahymena thermophile) | 3.5Â nM | 1 | DNA damage (20Â % DNA) | Gao et al. (2015) |
Chironomus riparius Larvae. | 35Â nM | 24 | DNA damage | MartÃnez-Paz et al. (2013) |