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Table 5 Reported triclosan (TCS) toxicities

From: Triclosan in water, implications for human and environmental health

Cell type

TCS Concentration (µM)

Exposure (h)

Toxicity

References

Human breast cancer cells MCF-7

≥345.4

120

Proliferation (oestrogenicity)

Henry and Fair (2013)

Human (A549) lung cancer cell

250

24

Cell membrane damage (LDH release)

Kwon et al. (2013)

Human (H460) lung cancer cell

10

24

Apoptotic and proliferative effect, Cell membrane damage (LDH release)

Winitthana et al. (2014)

Human PBMC

≥8.6

30

Loss of mitochondrial transmembrane potential; metabolic acidosis; uncoupling of oxidative phosphorylation

Ajao et al. (2015)

Human keratinocytes HaCaT

≥8.6

30

Loss of mitochondrial transmembrane potential; necrosis

Ajao et al. (2015)

Rat fibroblast cells (RBL)

≥5

1

Uncoupling of mitochondrial oxidative phosphorylation

Weatherly et al. (2016)

Human mast cells (HMC-1.2)

≥5

1

Mouse JB6 Cl 41-5a cells

≥8

≥48

Decreased growth; cell damage (increased LDH release); necrosis

Wu et al. (2015)

Zebrafish (Danio rerio, AB strain) embryos

15

1

Uncoupling of mitochondrial oxidative phosphorylation

Shim et al. (2016)

Freshwater Protozoan (Tetrahymena thermophile)

3.5 nM

1

DNA damage (20 % DNA)

Gao et al. (2015)

Chironomus riparius Larvae.

35 nM

24

DNA damage

Martínez-Paz et al. (2013)