Table 5 Mean plasma and brain pharmacokinetic parameters of quinidine in the presence and absence of silymarin and quercetin (10 mg/kg) after i.v. administration in mice

Dose (mg/kg)

5

10

10

5

10

10

Half life (h)

1.43

1.73

1.86

1.50

1.95

1.91

T_max (h)

0.66

0.50

0.50

0.80

0.50

0.83

C_max (ng/mL)

209.16

364.48

244.80

115.40

301.60

235.73

AUClast (h ng/mL)

496.40

680.43

445.29

211.40

635.15

390.09

AUCINF_obs (h ng/mL)

513.40

704.07

463.55

251.20

682.40

405.64