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Table 5 Mean plasma and brain pharmacokinetic parameters of quinidine in the presence and absence of silymarin and quercetin (10 mg/kg) after i.v. administration in mice

From: Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs

Parameters Plasma pharmacokinetics Brain pharmacokinetics
Quinidine With silymarin With quercetin Quinidine With silymarin With quercetin
Dose (mg/kg) 5 10 10 5 10 10
Half life (h) 1.43 1.73 1.86 1.50 1.95 1.91
Tmax (h) 0.66 0.50 0.50 0.80 0.50 0.83
Cmax (ng/mL) 209.16 364.48 244.80 115.40 301.60 235.73
AUClast (h ng/mL) 496.40 680.43 445.29 211.40 635.15 390.09
AUCINF_obs (h ng/mL) 513.40 704.07 463.55 251.20 682.40 405.64