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Table 4 Mean plasma and brain pharmacokinetics parameters of quinidine in the presence and absence of elacridar after i.v. administration in mice

From: Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs

Parameters Plasma pharmacokinetics Brain pharmacokinetics
Quinidine (5 mg/kg) Quinidine with elacridar (5 mg/kg) Quinidine (5 mg/kg) Quinidine with elacridar (5 mg/kg)
Dose (mg/kg) 5 5 5 5
Half life (h) 1.43 2.15 1.50 0.88
Tmax (h) 0.66 0.50 0.80 0.83
Cmax (ng/mL) 209.16 185.87 115.40 2225.80
AUClast (h ng/mL) 496.40 459.80 211.40 4998.65
AUCINF_obs (h ng/mL) 513.40 523.83 251.20 5039.93