Table 4 Mean plasma and brain pharmacokinetics parameters of quinidine in the presence and absence of elacridar after i.v. administration in mice
Parameters | Plasma pharmacokinetics | Brain pharmacokinetics | ||
|---|---|---|---|---|
Quinidine (5Â mg/kg) | Quinidine with elacridar (5Â mg/kg) | Quinidine (5Â mg/kg) | Quinidine with elacridar (5Â mg/kg) | |
Dose (mg/kg) | 5 | 5 | 5 | 5 |
Half life (h) | 1.43 | 2.15 | 1.50 | 0.88 |
Tmax (h) | 0.66 | 0.50 | 0.80 | 0.83 |
Cmax (ng/mL) | 209.16 | 185.87 | 115.40 | 2225.80 |
AUClast (h ng/mL) | 496.40 | 459.80 | 211.40 | 4998.65 |
AUCINF_obs (h ng/mL) | 513.40 | 523.83 | 251.20 | 5039.93 |