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Table 3 Efflux ratio for digoxin in presence and absence of silymarin and quercetin in the Caco-2 cell lines

From: Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs

Treatment

AP-BL transport

10−8 cm/s

BL-AP transport

10−6 cm/s

Efflux ratio (BL-AP/AP-BL)

Digoxin (10 µM)

5.18

1.80

34.77 ± 14.02

Digoxin + Quercetin (50 µM)

5.92

1.23

20.79 ± 0.13

Digoxin + Quercetin (100 µM)

10.4

1.22

11.70 ± 0.21

Digoxin + Silymarin (50 µM)

5.51

1.64

29.69 ± 3.10

Digoxin + Silymarin (100 µM)

6.64

1.42

21.35 ± 0.50