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Table 1 LC-MS conditions followed to analyze quinidine and digoxin in plasma and cell culture samples

From: Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs

Compound

MRM transition

DP

CE

Mobile phase and column

Digoxin

798.5/651.4

85

21

Mobile phase A

0.1 % acetonitrile in milli Q water

Mobile phase B

0.1 % Formic acid in Acetonitrile

Column

Kinetex 50 mm (C18)

Quinidine

325.2/184.2

130

70

  1. MRM multiple reaction monitoring, DP declustering potential, CE collision energy
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