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Table 1 LC-MS conditions followed to analyze quinidine and digoxin in plasma and cell culture samples

From: Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs

Compound MRM transition DP CE Mobile phase and column
Digoxin 798.5/651.4 85 21 Mobile phase A
0.1 % acetonitrile in milli Q water
Mobile phase B
0.1 % Formic acid in Acetonitrile
Kinetex 50 mm (C18)
Quinidine 325.2/184.2 130 70
  1. MRM multiple reaction monitoring, DP declustering potential, CE collision energy