Fig. 3
Representative LC-MS chromatograms of Quinidine, a plasma concentration of Quinidine + Silymarin; b plasma concentration of Quinidine + Quercetin; c brain concentrations of Quinidine + Silymarin, and d brain concentrations of Quinidine + Quercetin after 2 h of administration. The left lane peaks are quinidine alone and right lane in presence of Silymarin/Quercetin. The shift in retention time in respective chromatograms indicates significant increase in the area under the curve in comparison to the quinidine alone peaks indicating effective P-gp inhibition in presence of drug treatment