Table 1 The top 100 cited publications in paracetamol poisoning treatment ranked in descending order of the number of citations
SCR | Authors | Title | Year | Source title | Cited by | Document type | IFa | Citation index | Country of corresponding author | Collaboration country |
|---|---|---|---|---|---|---|---|---|---|---|
1st | Smilkstein et al. (1988) | Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the National Multicenter Study (1976 to 1985) | 1988 | New England Journal of Medicine | 553 | Article | 55.873 | 20.5 | USA | Â |
2nd | James et al. (2003) | Acetaminophen-induced hepatotoxicity | 2003 | Drug Metabolism and Disposition | 511 | Review | 3.252 | 42.6 | USA | Â |
3rd | Prescott et al. (1979) | Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning | 1979 | British Medical Journal | 419 | Article | 17.445 | 11.6 | UK | Â |
4th | Harrison et al. (1991) | Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure | 1991 | New England Journal of Medicine | 340 | Article | 55.873 | 14.2 | UK | Â |
5th | Kelly (1998) | Clinical applications of N-acetylcysteine | 1998 | Alternative Medicine Review | 297 | Article | 3.833 | 17.5 | USA | Â |
6th | Keays et al. (1991) | Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial | 1991 | British Medical Journal | 275 | Article | 17.445 | 11.5 | UK | Â |
7th | Mitchell et al. (1974) | Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy | 1974 | Clinical Pharmacology and Therapeutics | 258 | Article | 7.903 | 6.3 | USA | Â |
8th | Seeff et al. (1986) | Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure | 1986 | Annals of Internal Medicine | 252 | Review | 17.810 | 8.7 | USA | Â |
9th | Lee (2004) | Acetaminophen and the US acute liver failure study group: lowering the risks of hepatic failure | 2004 | Hepatology | 250 | Review | 11.055 | 22.7 | USA | Â |
10th | Rumack et al. (1981) | Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment | 1981 | Archives of Internal Medicine | 245 | Article | 17.333 | 7.2 | USA | Â |
11th | Harrison et al. (1990) | Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine | 1990 | The Lancet | 239 | Article | 45.217 | 9.6 | UK | Â |
12th | Makin et al. (1995) | A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987–1993) | 1995 | Gastroenterology | 237 | Article | 16.716 | 11.9 | UK |  |
13th | Forrest et al. (1982) | Clinical pharmacokinetics of paracetamol | 1982 | Clinical Pharmacokinetics | 221 | Review | 5.053 | 6.7 | UK | Â |
14th | Prescott (1983) | Paracetamol overdosage. Pharmacological considerations and clinical management | 1983 | Drugs | 219 | Review | 4.343 | 6.8 | UK | Â |
15th | Atkuri et al. (2007) | N-acetylcysteine—a safe antidote for cysteine/glutathione deficiency | 2007 | Current Opinion in Pharmacology | 211 | Review | 4.595 | 26.4 | USA |  |
16th | Lee et al. (2009) | Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure | 2009 | Gastroenterology | 180 | Article | 16.716 | 30.0 | USA | Â |
17th | Black (1984) | Acetaminophen hepatotoxicity | 1984 | Annual Review of Medicine | 178 | Review | 12.928 | 5.7 | USA | Â |
18th | Prescott et al. (1977) | Treatment of paracetamol (acetaminophen) poisoning with n-acetylcysteine | 1977 | The Lancet | 175 | Article | 45.217 | 4.6 | UK | Â |
19th | Holdiness (1991) | Clinical pharmacokinetics of N-acetylcysteine | 1991 | Clinical Pharmacokinetics | 172 | Review | 5.053 | 7.2 | USA | Â |
19th | Smilkstein et al. (1991) | Acetaminophen overdose: a 48-h intravenous N-acetylcysteine treatment protocol | 1991 | Annals of Emergency Medicine | 172 | Article | 4.676 | 7.2 | USA | Â |
21st | Burgunder et al. (1989) | Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration | 1989 | European Journal of Clinical Pharmacology | 163 | Article | 2.966 | 6.3 | Switzerland | Â |
22nd | Lauterburg and Velez (1988) | Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity | 1988 | Gut | 159 | Article | 14.660 | 5.9 | Switzerland | USA |
23rd | Larson (2007) | Acetaminophen hepatotoxicity | 2007 | Clinics in Liver Disease | 158 | Review | 3.660 | 19.8 | USA | Â |
24th | Rumack(2002) | Acetaminophen hepatotoxicity: the first 35 years | 2002 | Journal of Toxicology—Clinical Toxicology | 148 | Conference Paper | 3.673 | 11.4 | USA |  |
25th | Thomas (1993) | Paracetamol (acetaminophen) poisoning | 1993 | Pharmacology and Therapeutics | 141 | Article | 9.723 | 6.4 | UK | Â |
26th | Bernal et al. (1998) | Use and outcome of liver transplantation in acetaminophen-induced acute liver failure | 1998 | Hepatology | 134 | Article | 11.055 | 7.9 | UK | Â |
27th | Dodd et al. (2008) | N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility | 2008 | Expert Opinion on Biological Therapy | 133 | Review | 3.743 | 19.0 | Australia | Â |
28th | Heard (2008) | Acetylcysteine for acetaminophen poisoning | 2008 | New England Journal of Medicine | 130 | Article | 55.873 | 18.6 | USA | Â |
29th | Chun et al. (2009) | Acetaminophen hepatotoxicity and acute liver failure | 2009 | Journal of Clinical Gastroenterology | 121 | Review | 3.498 | 20.2 | USA | Â |
30th | Flanagan and Meredith (1991) | Use of N-acetylcysteine in clinical toxicology | 1991 | The American Journal of Medicine | 117 | Article | 5.003 | 4.9 | UK | Â |
31st | Mant et al. (1984) | Adverse reactions to acetylcysteine and effects of overdose | 1984 | British Medical Journal | 115 | Article | 17.445 | 3.7 | UK | Â |
32nd | Prescott et al. (1989) | The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage | 1989 | European Journal of Clinical Pharmacology | 114 | Article | 2.966 | 4.4 | UK | Â |
33rd | Daly et al. (2008) | Guidelines for the management of paracetamol poisoning in Australia and New Zealand—explanation and elaboration | 2008 | Medical Journal of Australia | 109 | Article | 4.089 | 15.6 | Australia | New Zealand |
34th | Nourjah et al. (2006) | Estimates of acetaminophen (paracetamol)-associated overdoses in the United States | 2006 | Pharmacoepidemiology and Drug Safety | 103 | Article | 2.939 | 11.4 | USA | Â |
34th | Schmidt et al. (2002) | Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity | 2002 | Hepatology | 103 | Article | 11.055 | 7.9 | Denmark | Â |
36th | Rumack and Peterson (1978) | Acetaminophen overdose: incidence, diagnosis, and management in 416 patients | 1978 | Pediatrics | 102 | Article | 5.473 | 2.8 | USA | Â |
37th | Mazer and Perrone(2008) | Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. | 2008 | Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology | 96 | Review | NA | 13.7 | USA | Â |
38th | Jones (1998) | Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: a critical review | 1998 | Journal of Toxicology—Clinical Toxicology | 94 | Review | 3.673 | 5.5 | UK |  |
39th | Ward et al. (2001) | Acetaminophen toxicity in children | 2001 | Pediatrics | 93 | Review | 5.473 | 6.6 | USA | Canada |
39th | Prescott et al. (1976) | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning | 1976 | The Lancet | 93 | Article | 45.217 | 2.4 | UK | Â |
41st | Penna and Buchanan (1991) | Paracetamol poisoning in children and hepatotoxicity | 1991 | British Journal of Clinical Pharmacology | 92 | Review | 3.878 | 3.8 | Australia | Â |
42nd | Prescott and Critchley (1983) | The treatment of acetaminophen poisoning | 1983 | Annual Review of Pharmacology and Toxicology | 90 | Review | 18.365 | 2.8 | UK | Â |
43rd | Prescott (2000) | Paracetamol: past, present, and future | 2000 | American Journal of Therapeutics | 89 | Article | 1.129 | 5.9 | UK | Â |
44th | Buckley et al. (1999b) | Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? | 1999 | Journal of Toxicology—Clinical Toxicology | 88 | Article | 3.673 | 5.5 | Australia |  |
45th | Antoine et al. (2013) | Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital | 2013 | Hepatology | 84 | Article | 11.055 | 42.0 | UK | Switzerland |
46th | Mitchell et al. (1998) | Earlier identification of patients at risk from acetaminophen-induced acute liver failure | 1998 | Critical Care Medicine | 83 | Article | 6.312 | 4.9 | UK | Â |
46th | Slattery et al. (1987) | Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans | 1987 | Clinical Pharmacology and Therapeutics | 83 | Article | 7.903 | 3.0 | USA | Â |
48th | Millea (2009) | N-acetylcysteine: multiple clinical applications | 2009 | American Family Physician | 79 | Review | 2.175 | 13.2 | USA | Â |
49th | Samuni et al. (2013) | The chemistry and biological activities of N-acetylcysteine | 2013 | Biochimica et BiophysicaActa—General Subjects | 76 | Review | 4.381 | 38.0 | Australia | Israel |
50th | Winnike et al. (2010) | Use of pharmaco-metabonomics for early prediction of acetaminophen-induced hepatotoxicity in humans | 2010 | Clinical Pharmacology and Therapeutics | 75 | Article | 7.903 | 15.0 | USA | Â |
50th | Rumack (1984) | Acetaminophen overdose in young children: treatment and effects of alcohol and other additional ingestants in 417 cases | 1984 | American Journal of Diseases of Children | 75 | Article | Stop | 2.4 | USA | Â |
52nd | Kerr et al. (2005) | The Australasian clinical toxicology investigators collaboration randomized trial of different loading infusion rates of N-acetylcysteine | 2005 | Annals of Emergency Medicine | 74 | Article | 4.676 | 7.4 | Australia | Â |
53rd | Aitio(2006) | N-acetylcysteine—passe-partout or much ado about nothing? | 2006 | British Journal of Clinical Pharmacology | 73 | Review | 3.878 | 8.1 | Switzerland |  |
53rd | Detry et al. (1999) | Clinical use of a bioartificial liver in the treatment of acetaminophen-induced fulminant hepatic failure | 1999 | American Surgeon | 73 | Article | 0.818 | 4.6 | USA | Â |
55th | Dart et al. (2006) | Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management | 2006 | Clinical Toxicology | 72 | Review | 3.673 | 8.0 | USA | Â |
56th | Eguia and Materson (1997) | Acetaminophen-related acute renal failure without fulminant liver failure | 1997 | Pharmacotherapy | 71 | Article | 2.662 | 3.9 | USA | Â |
56th | Dawson et al. (1989) | Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning | 1989 | Medical Journal of Australia | 71 | Article | 4.089 | 2.7 | Australia | Â |
58th | Schmidt and Dalhoff (2001) | Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning | 2001 | British Journal of Clinical Pharmacology | 70 | Article | 3.878 | 5.0 | DenmarK | Â |
59th | Woo et al. (2000) | Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose | 2000 | Annals of Emergency Medicine | 68 | Article | 4.676 | 4.5 | USA | Â |
60th | Buckley et al. (1999a) | Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen (paracetamol) overdose | 1999 | Journal of Toxicology—Clinical Toxicology | 67 | Article | 3.673 | 4.2 | Australia |  |
61st | Ziment (1988) | Acetylcysteine: a drug that is much more than a mucokinetic | 1988 | Biomedicine and Pharmacotherapy | 66 | Review | 2.023 | 2.4 | USA | Â |
62nd | James et al. (2009) | Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure | 2009 | Drug Metabolism and Disposition | 64 | Article | 3.252 | 10.7 | USA | Â |
62nd | Fontana (2008) | Acute liver failure including acetaminophen overdose | 2008 | Medical Clinics of North America | 64 | Review | 2.607 | 9.1 | USA | Â |
64th | Benson et al. (2005) | The therapeutic use of acetaminophen in patients with liver disease | 2005 | American Journal of Therapeutics | 63 | Review | 1.129 | 6.3 | USA | Â |
64th | Bray et al. (1992) | Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure | 1992 | Human and Experimental Toxicology | 63 | Article | 1.747 | 2.7 | Denmark | Â |
66th | Prescott (2005) | Oral or intravenous N-acetylcysteine for acetaminophen poisoning? | 2005 | Annals of Emergency Medicine | 61 | Editorial | 4.676 | 6.1 | UK | Â |
66th | Perry and Shannon (1998) | Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial | 1998 | Journal of Pediatrics | 61 | Article | 3.790 | 3.6 | USA | Â |
68th | Sandilands and Bateman (2009) | Adverse reactions associated with acetylcysteine Adverse reactions associated with acetylcysteine | 2009 | Clinical Toxicology | 60 | Review | 3.673 | 10.0 | UK | Â |
68th | Ferner et al. (2001) | Random and systematic medication errors in routine clinical practice: a multicentre study of infusions, using acetylcysteine as an example | 2001 | British Journal of Clinical Pharmacology | 60 | Article | 3.878 | 4.3 | UK | Â |
68th | O’Grady et al. (1991) | Liver transplantation after paracetamol overdose | 1991 | British Medical Journal | 60 | Article | 17.445 | 2.5 | UK |  |
71st | Kanter (2006) | Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning | 2006 | American Journal of Health-System Pharmacy | 59 | Review | 1.882 | 6.6 | USA | Â |
72nd | Appelboam et al. (2002) | Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma | 2002 | Emergency Medicine Journal | 58 | Article | 1.843 | 4.5 | UK | Â |
72nd | Gazzard et al. (1975) | Early changes in coagulation following a paracetamol overdose and a controlled trial of fresh frozen plasma therapy | 1975 | Gut | 58 | Article | 14.660 | 1.5 | UK | Â |
74th | Kortsalioudaki et al. (2008) | Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure | 2008 | Liver Transplantation | 57 | Article | 4.241 | 8.1 | UK | Â |
74th | Mutimer et al. (1994) | Serious paracetamol poisoning and the results of liver transplantation | 1994 | Gut | 57 | Article | 14.660 | 2.7 | UK | Â |
74th | Jones and Vale (1993) | Paracetamol poisoning and the kidney | 1993 | Journal of Clinical Pharmacy and Therapeutics | 57 | Review | 1.668 | 2.6 | UK | Â |
77th | Kao et al. (2003) | What Is the rate of adverse events after oral N-acetylcysteine Administered by the intravenous route to patients with suspected acetaminophen poisoning? | 2003 | Annals of Emergency Medicine | 56 | Review | 4.676 | 4.7 | US | Â |
77th | Wallace et al. (2002) | Paracetamol overdose: an evidence based flowchart to guide management | 2002 | Emergency Medicine Journal | 56 | Article | 1.843 | 4.3 | UK | Â |
79th | McClain et al. (1999) | Acetaminophen hepatotoxicity: an update | 1999 | Current gastroenterology reports | 55 | Review | NA | 3.4 | USA | Â |
79th | Makin and Williams (1997) | Acetaminophen-induced hepatotoxicity: predisposing factors and treatments | 1997 | Advances in internal medicine | 55 | Review | NA | 3.1 | UK | Â |
79th | Prescott (1981) | Treatment of severe acetaminophen poisoning with intravenous acetylcysteine | 1981 | Archives of Internal Medicine | 55 | Article | 17.333 | 1.6 | UK | Â |
82nd | Murphy et al. (1990) | Severe acetaminophen toxicity in a patient receiving isoniazid | 1990 | Annals of Internal Medicine | 53 | Article | 17.810 | 2.1 | USA | Â |
83rd | Daly et al. (2004) | Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion | 2004 | Annals of Emergency Medicine | 52 | Article | 4.676 | 4.7 | USA | Â |
83rd | Kozer et al. (2003) | Glutathione, glutathione-dependent enzymes and antioxidant status in erythrocytes from children treated with high-dose paracetamol | 2003 | British Journal of Clinical Pharmacology | 52 | Article | 3.878 | 4.3 | Israel | Â |
83rd | Prince et al. (2000) | Reduction in incidence of severe paracetamol poisoning | 2000 | The Lancet | 52 | Note | 45.217 | 3.5 | UK | Â |
83rd | Riggs et al. (1989) | Acute acetaminophen overdose during pregnancy | 1989 | Obstetrics and Gynecology | 52 | Article | 5.175 | 2.0 | USA | Â |
87th | Khandelwal et al. (2011) | Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure | 2011 | Hepatology | 51 | Article | 11.055 | 12.8 | USA | Â |
87th | Yarema et al. (2009) | Comparison of the 20-h intravenous and 72-h oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning | 2009 | Annals of Emergency Medicine | 51 | Article | 4.676 | 8.5 | Canada | USA |
87th | Lynch and Robertson (2004) | Anaphylactoid reactions to intravenous N-acetylcysteine: a prospective case controlled study | 2004 | Accident and Emergency Nursing (Continue as International Emergency Nursing) | 51 | Article | 0.703 | 4.6 | UK | Â |
90th | Ferner et al. (2011) | Management of paracetamol poisoning | 2011 | British Medical Journal | 50 | Review | 17.445 | 12.5 | UK | Â |
90th | Mahadevan et al. (2006) | Paracetamol induced hepatotoxicity | 2006 | Archives of Disease in Childhood | 50 | Review | 2.899 | 5.6 | UK | Â |
90th | Gyamlani and Parikh (2002) | Acetaminophen toxicity: suicidal versus accidental | 2002 | Critical Care | 50 | Article | 4.476 | 3.8 | USA | Â |
90th | Underhill et al. (1990) | A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose | 1990 | Archives of Emergency Medicine (Continue as Emergency Medicine Journal) | 50 | Article | 1.843 | 2.0 | UK | Â |
94th | Waring et al. (2008c) | Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose | 2008 | Clinical Toxicology | 49 | Article | 3.673 | 7.0 | UK | Â |
94th | Whyte et al. (2000) | Acetaminophen causes an increased international normalized ratio by reducing functional factor VII | 2000 | Therapeutic Drug Monitoring | 49 | Article | 2.376 | 3.3 | Australia | Â |
94th | Anderson et al. (1999) | Predicting concentrations in children presenting with acetaminophen overdose | 1999 | Journal of Pediatrics | 49 | Article | 3.790 | 3.1 | New Zealand | Â |
97th | Rumack (1986) | Acetaminophen overdose in children and adolescents | 1986 | Pediatric Clinics of North America | 48 | Article | 2.120 | 1.7 | USA | Â |
98th | Marzullo (2005) | An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children | 2005 | Current Opinion in Pediatrics | 47 | Review | 2.528 | 4.7 | USA | Â |
99th | Sivilotti et al. (2005) | A risk quantification instrument for acute acetaminophen overdose patients treated with n-acetylcysteine | 2005 | Annals of Emergency Medicine | 44 | Article | 4.676 | 4.6 | Canada | USA |
99th | Schiodt et al. (2002) | Influence of acute and chronic alcohol intake on the clinical course and outcome in acetaminophen overdose | 2002 | Alimentary Pharmacology and Therapeutics | 44 | Article | 5.727 | 3.5 | Denmark | USA |
99th | Pakravan et al. (2008) | Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose | 2008 | Clinical Toxicology | 44 | Article | 3.673 | 6.3 | UK | Â |