Characteristics of CpG Islands and their quasispecies of full-length hepatitis B virus genomes from patients at different phases of infection

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Table 1 Demographic and clinical features of patients (mean ± SE)

	AHB (n = 10)	IT (n = 9)	CHB (n = 11)	ACLF (n = 10)	P value
Sex (M/F)	9/1	5/4	6/5	10/0	0.032
Age (year)	40.70 ± 2.62	28.56 ± 1.84^a,b	35.55 ± 3.89	43.80 ± 2.82	0.008
ALT (U/L)	1608.5 ± 199.29	29.67 ± 3.76^a,b	263.45 ± 131.04^c,d	1171.57 ± 184.49	0.001
TBIL (μmol/L)	327.62 ± 130.01	16.01 ± 1.40^a,b	32.95 ± 9.36^c,d	301.79 ± 29.83	0.002
PTA (%)	77.89 ± 5.45	103.33 ± 3.33	98.79 ± 1.21	30.58 ± 2.65^b,d,e	0.000
HBeAg (±)	10/0	9/0	10/1	2/8^b,d,e	0.000
HBV DNA (log₁₀IU/ml)	6.55 ± 0.45	8.02 ± 0.19^a,b	7.09 ± 0.38	6.34 ± 0.26	0.011
Genotype (B/C)	4/6	3/6	6/5	5/5	0.777

The proportions of patients harboring HBV genotype B and C did not differ significantly among the four groups (P > 0.05)
AHB acute hepatitis B, IT immune-tolerance, CHB chronic hepatitis B, ACLF acute on chronic liver failure, ALT alanine aminotransferase, TBIL total bilirubin, PTA prothrombin time activity
^a P < 0.01 IT versus AHB, ^b P < 0.01 IT versus ACLF, ^c P < 0.01 CHB versus AHB, ^d P < 0.01 CHB versus ACLF, ^e P < 0.01 AHB versus ACLF