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Table 1 Demographic and clinical features of patients (mean ± SE)

From: Characteristics of CpG Islands and their quasispecies of full-length hepatitis B virus genomes from patients at different phases of infection

  AHB (n = 10) IT (n = 9) CHB (n = 11) ACLF (n = 10) P value
Sex (M/F) 9/1 5/4 6/5 10/0 0.032
Age (year) 40.70 ± 2.62 28.56 ± 1.84a,b 35.55 ± 3.89 43.80 ± 2.82 0.008
ALT (U/L) 1608.5 ± 199.29 29.67 ± 3.76a,b 263.45 ± 131.04c,d 1171.57 ± 184.49 0.001
TBIL (μmol/L) 327.62 ± 130.01 16.01 ± 1.40a,b 32.95 ± 9.36c,d 301.79 ± 29.83 0.002
PTA (%) 77.89 ± 5.45 103.33 ± 3.33 98.79 ± 1.21 30.58 ± 2.65b,d,e 0.000
HBeAg (±) 10/0 9/0 10/1 2/8b,d,e 0.000
HBV DNA (log10IU/ml) 6.55 ± 0.45 8.02 ± 0.19a,b 7.09 ± 0.38 6.34 ± 0.26 0.011
Genotype (B/C) 4/6 3/6 6/5 5/5 0.777
  1. The proportions of patients harboring HBV genotype B and C did not differ significantly among the four groups (P > 0.05)
  2. AHB acute hepatitis B, IT immune-tolerance, CHB chronic hepatitis B, ACLF acute on chronic liver failure, ALT alanine aminotransferase, TBIL total bilirubin, PTA prothrombin time activity
  3. a P < 0.01 IT versus AHB, b P < 0.01 IT versus ACLF, c P < 0.01 CHB versus AHB, d P < 0.01 CHB versus ACLF, e P < 0.01 AHB versus ACLF