Downward trend in the prevalence of Helicobacter pylori infections and corresponding frequent upper gastrointestinal diseases profile changes in Southeastern China between 2003 and 2012

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Table 1 Baseline statistics for age, gender and H. pylori infections in UGID patients from 2003 to 2012

Characteristics	Hp (+)		Hp (−)		OR	95 % CI	P value
Characteristics	Number	%	Number	%	OR	95 % CI	P value
Gender^a							<0.001
Male	23,883	35.20	43,976	64.80
Female	19,197	28.69	47,718	71.31
Age							<0.001
≤19	893	30.99	1989	69.01
20–29	4426	35.50	8040	64.50
30–39	9094	34.79	17,043	65.21
40–49	10,863	33.35	21,712	66.05
50–59	9786	31.04	21,737	68.96
60–69	5487	27.94	14,151	72.06
≥70	2546	26.55	7045	73.45
Year							<0.001
2003	3458	42.40	4698	57.60
2004	4602	40.43	6781	59.57
2005	4274	34.82	8001	65.18
2006	4647	37.22	7837	62.78
2007	5269	35.77	9460	64.23
2008	4402	31.20	9709	68.80
2009	4528	29.10	11,033	70.90
2010	4485	28.14	11,454	71.86
2011	3859	25.41	11,326	74.59
2012	3571	23.82	11,418	76.18
CG	30,920	27.41	81,885	72.59
DU	7280	67.80	3457	32.20	5.58	5.34–5.82	<0.001*
GU	3293	55.70	2619	44.30	3.33	3.16–3.51	<0.001*
GC	1497	33.31	2997	66.69	1.07	1.00–1.13	0.049
RE					0.85	0.82–0.88	<0.001
Presence	4407	28.87	10,859	71.13
Absence	38,688	32.36	80,858	67.64

Chi square test was used to calculate the statistical differences of H. pylori infections, gender and various UGID groups. The Cochran–Mantel–Haenszel Chi square test was used to identify the liner trend between H. pylori infections and years
CG chronic gastritis, DU duodenal ulcer, GU gastric ulcer, GC gastric cancer, DGIMs diseases of gastrointestinal motility, RE reflux esophagitis, Hp H. pylori
^aSince some patient information subsets were incomplete, the sum of patients for some data subsets is less than the total population of 134.812
* The DU and GU groups were compared with patients in the simple CG group without DU, GU and other digestive diseases such as gastric cancer. Compound ulcers (only 543 cases) were assigned into the DU or GU group