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Table 1 The mean IC50 of MDIs for the inhibition of LPS-stimulated IL-1β production in MKD-like THP-1 cells

From: Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition

MDI

IC50 (nmol/L)

95 % confidence interval

GGPP

1.5

1.1–1.9

FPP

1179

856–1625

GGOH

369

282–483

FOH

ND

ND

  1. ND not determined
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