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Scheme 1

From: Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition

Scheme 1

Chemical structures of TAK-475 and TAK-475 M-I. TAK-475, 1-{[(3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl}piperidine-4-acetic acid (C33H41ClN2O9) is quickly hydrolyzed to TAK-475 M-I during the in vivo absorption process as shown in Scheme 1

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