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Fig. 6 | SpringerPlus

Fig. 6

From: Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition

Fig. 6

TAK-475 M-I inhibited LPS-stimulated IL-1β production in MKD-like THP-1 cells. IL-1β protein concentration in culture supernatants of LPS-stimulated MKD-like THP-1 cells was measured using ELISA. Inserted figure is an enlarged view of the region at 3 μmol/L simvastatin and 1 ng/mL of LPS. Data are represented as mean + SD, n = 3. Statistical significance was determined by a Williams’ test with significance set at *P < 0.025 and **P < 0.005 (versus 0 nmol/L of TAK475 M-I in each experimental condition). ND: not detected

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