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Fig. 5 | SpringerPlus

Fig. 5

From: Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition

Fig. 5

GGPP and FPP showed a tendency to have cytoprotective effects in LPS-stimulated MKD-like human PBMCs. Damaged cell ratio (DCR) was measured using ToxiLight bioassay kit (Lonza) and expressed the ratio of AK activity from AK-released cells against that from total cells. Data are represented as mean + SD, n = 3. The cytotoxicity of simvastatin and LPS in PBMCs was evaluated by a Dunnett’s test with significance set at # P < 0.05 and ## P < 0.01 (versus 0 μmol/L of MDI without simvastatin and LPS). The effects of GGPP and FPP in LPS-stimulated MKD-like PBMCs were evaluated by a Dunnett’s test. *P < 0.05 (versus 0 μmol/L of MDI with LPS and simvastatin)

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