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Fig. 3 | SpringerPlus

Fig. 3

From: Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition

Fig. 3

MDIs significantly inhibited cytotoxicity measured by DCR in LPS-stimulated MKD-like THP-1 cells. Damaged cell ratio was measured in triplicates using ToxiLight bioassay kit (Lonza, Basel, Switerland) and expressed the ratio of AK activity from AK-releasing cells against that from total cells. Data are represented as mean + SD, n = 3. The cytotoxicity of LPS was evaluated by a Student’s t-test with significance set at ### P < 0.001 (versus 0 μmol/L of MDI and 0 ng/mL of LPS). The dose-dependent effects of MDIs in LPS-stimulated MKD-like THP-1 cells were evaluated by a two-tailed Williams’ test with significance set at **P < 0.01 and ***P < 0.001 (versus 0 μmol/L of MDI and 10 ng/mL of LPS)

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