Fig. 2From: Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like conditionGGPP, FPP and GGOH inhibited LPS-stimulated IL-1β production in MKD-like THP-1 cells. IL-1β protein concentration in culture supernatants of LPS-stimulated MKD-like THP-1 monocyte cells was measured using ELISA. Data are represented as mean ± SD, n = 3Back to article page