Fig. 1From: Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like conditionFPP, FOH and GGPP but not GGOH were increased in a dose-dependent trend in 48 h treatment of TAK-475 M-I. THP-1 cells were stimulated with various concentrations of TAK-475 M-I for 48 h. FOH, FPP, GGOH and GGPP in the cells were quantified by LC–MS/MSBack to article page