Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods

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Table 5 Summary of the inhibitory effects [expressed as IC₅₀ (μg/ml) and volume per dose index (VDI, L/dose unit)] of Huang-Qin (HQ) extracts prepared by different extraction methods on model probes’ metabolism

Samples	CYP1A2		CYP2C9		CYP2D6		CYP3A4
Samples	IC₅₀	VDI	IC₅₀	VDI	IC₅₀	VDI	IC₅₀	VDI
HRE-W	8.13 ± 0.08	80.0	38.87 ± 0.60	16.7	131.3 ± 5.35	4.95	174.1 ± 4.86	3.74
MAE-W	7.42 ± 0.20*	87.6	30.71 ± 0.84***	21.2	135.3 ± 6.43	4.80	243.0 ± 11.81**	2.68
UE-E	3.00 ± 0.12***	216.7	11.25 ± 0.66***	57.8	38.29 ± 1.28***	17.0	106.6 ± 4.53**	6.10
Positive controls^a	0.640	–	0.138	–	0.292	–	0.047	–

Results are expressed as mean ± SEM (n = 3)
* P < 0.05; ** P < 0.01 and *** P < 0.001 compared to HRE-W
^aFurafylline for CYP1A2; Sulfaphenazole for CYP2C9; Quinidine for CYP2D6; Ketoconazole for CYP3A4. Results of the positive controls included in this Table for comparison have been published in our previous work (Wang et al. 2010; Zhou et al. 2012b)