Structural connectivity profile of scans without evidence of dopaminergic deficit (SWEDD) patients compared to normal controls and Parkinson’s disease patients

Kim, Mansu; Park, Hyunjin

doi:10.1186/s40064-016-3110-8

SpringerPlus

Table 3 Correlation between the structural connectivity and MDS-UPDRS III score

From: Structural connectivity profile of scans without evidence of dopaminergic deficit (SWEDD) patients compared to normal controls and Parkinson’s disease patients

Connections	Structural connectivity (mean ± SD)				Corr coef. (corrected p value)
Connections	NC	SWEDD	PD	Total	Corr coef. (corrected p value)
Associative cortex–caudate	0.671 ± 1.381	0.299 ± 0.453	0.232 ± 0.319	0.401 ± 0.874	−0.171 (0.61)
Associative cortex–putamen	3.452 ± 1.561	3.471 ± 1.517	3.734 ± 1.771	3.552 ± 1.612	0.034 (1)
Associative cortex–thalamus	0.833 ± 0.488	0.650 ± 0.367	1.173 ± 0.750	0.886 ± 0.595	0.088 (1)
Limbic cortex–caudate	2.197 ± 1.463	1.902 ± 1.310	0.710 ± 1.215	1.603 ± 1.471	−0.404 (<0.001)
Limbic cortex–putamen	3.175 ± 1.272	3.271 ± 1.474	2.557 ± 1.147	3.001 ± 0.132	−0.070 (1)
Limbic cortex–thalamus	1.535 ± 0.810	1.379 ± 0.866	1.054 ± 0.889	1.323 ± 0.872	−0.239 (0.104)
Sensorimotor cortex–caudate	0.430 ± 0.993	0.170 ± 0.471	0.053 ± 0.076	0.217 ± 0.638	−0.161 (0.711)
Sensorimotor cortex–putamen	1.250 ± 0.742	1.485 ± 0.930	1.728 ± 1.108	1.488 ± 0.951	0.280 (0.014)
Sensorimotor cortex–thalamus	0.964 ± 0.574	0.947 ± 0.537	1.019 ± 0.703	0.977 ± 0.605	0.076 (1)
Pallidum–caudate	0.676 ± 0.644	0.838 ± 0.744	0.631 ± 0.825	0.715 ± 0.741	−0.099 (1)
Pallidum–putamen	2.166 ± 0.898	1.840 ± 0.917	1.283 ± 0.522	1.766 ± 0.873	−0.352 (0.001)
Pallidum–thalamus	0.799 ± 0.519	0.926 ± 0.523	0.565 ± 0.452	0.763 ± 0.517	−0.183 (0.54)
Putamen–thalamus	0.439 ± 0.437	0.477 ± 0.388	0.346 ± 0.298	0.421 ± 0.380	−0.177 (0.572)
Substantia nigra–putamen	0.004 ± 0.017	0.001 ± 0.004	0.004 ± 0.015	0.003 ± 0.013	0.037 (1)
Substantia nigra–thalamus	0.001 ± 0.005	0.004 ± 0.012	0.009 ± 0.003	0.003 ± 0.009	0.103 (1)
Substantia nigra–pallidum	0.096 ± 0.243	0.095 ± 0.363	0.160 ± 0.129	0.117 ± 0.261	−0.017 (0.851)

Structural connectivity values based on fiber density were reported for 16 connections within the CBGT circuit. Correlation between the structural connectivity and MDS-UPDSR scores is reported as the Spearman correlation coefficient with the corrected p value in the rightmost column. The italicised text shows identified connections with significant group-wise differences in NC-PD, SWEDD-NC and SWEDD-PD comparisons as reported in Table 2

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