Table 1 Characteristics of eligible studies included in the meta-analysis
Study | Patient source | Study duration | Follow-up duration (range), months | Method | Antibody source for IHC | Dilution of antibody | Defination of positivity | Histology type | Mean age (range), years | Number of patients | HIF + (%) | Study design | NOS score | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Zhao et al. (2015) | China | 2002–2012 | NR (3–107) | IHC | Novus | 1:100 | >25 % | OS | NR | 88 | 56.8 | Re | M | 7 |
Kim et al. (2015) | Korea | 1998–2007 | 38 (2–187) | IHC | Abcam | 1:1000 | >50 % | STS | 57 (1–82) | 55 | 54.5 | Re | S | 8 |
Hu et al. (2015) | China | 2006–2011 | 36 | IHC | Proteintech | 1:200 | SS | OS | NR | 50 | 58.0 | Pro | M | 9 |
Guo et al. (2014) | China | 2003–2007 | NR | IHC | Abcam | 1:200 | >10 % | OS | NR | 98 | 79.9 | Re | S | 7 |
Smeland et al. (2012) | Norway and Russia | 1973–2006 | 37.6 (0.1–391.7) | IHC | Novus | 1: 3500 | SS | STS | 60 (0–91) | 200 | 61.5 | Re | M | 8 |
Chen et al. (2011) | China | NR | 34 (4–98) | IHC | Abcam | 1:50 | >10 % | CS | 47.9 (18–72) | 34 | 58.8 | Re | S | 8 |
China | 2000–2009 | 29 (6–100) | IHC | Santa | 1:100 | SS | OS | 18.5 (11–72) | 49 | 55.1 | Pro | S | 9 | |
Zeng et al. (2010) | China | NR | NR | IHC | NR | 1:100 | SS | OS | 18.6 (7–49) | 45 | 55.6 | Re | S | 7 |
Huang et al. (2010) | USA | 1987–2006 | 27.5 (0.7–229) | IHC | Labvision | NR | >10 % | STS | 64 (21–85) | 39 | 41.0 | Re | S | 7 |
Boeuf et al. (2010) | Germany | NR | 116.3 | IHC | BD | 1:1250 | SS | CS | NR | 65 | 33.8 | Re | M | 8 |
Hoffmann et al. (2009) | Germany | NR | NR | RT-RCP | – | – | NR | STS | 57 (16–85) | 45 | 64.4 | Re | S | 7 |
Mizobuchi et al. (2008) | USA | NR | NR | IHC | Novus | 1:100 | SS | OS | 21 (7–38) | 48 | 37.5 | Re | S | 7 |
Kubo et al. (2008) | Japan | 1986–2001 | 78 (1–192) | IHC | Novus | 1:1000 | >10 % | CS | 42 (15–71) | 20 | 40.0 | Re | S | 8 |
Chen et al. (2008) | China | NR | NR | IHC | NeoMarkers | 1:70 | SS | OS | NR (3–63) | 25 | 68.0 | Re | S | 6 |
Yang et al. (2007) | China | NR | 50 (13–86) | IHC | Santa | 1:50 | SS | OS | 19 (5–56) | 39 | 43.6 | Re | S | 8 |
Shintani et al. (2006) | Japan | NR | 39 (5–181) | IHC | Novus | 1:1000 | SS | STS | 63 (12–85) | 42 | 52.4 | Re | S | 7 |