Table 5 Selected pharmacokinetic parameters of Donepezil (Chair Form) and its derivatives
Parameters | Donepezil | D1 | D2 | D3 | D4 | D5 |
|---|---|---|---|---|---|---|
Blood Brain Barrier | + (0.9953) | + (0.9931) | + (0.9921) | + (0.9911) | + (0.9887) | + (0.9941) |
Human Intestinal Absorption | + (0.9566) | + (0.9962) | + (0.9963) | + (0.9946) | + (0.9802) | + (1.0000) |
P-glycoprotein Inhibitor | Inhibitor (0.7641) | Inhibitor (0.8388) | Inhibitor (0.7572) | Inhibitor (0.8138) | Inhibitor (0.8185) | Inhibitor (0.7949) |
Human Ether-a-go–go-Related (hERG) Gene Inhibition | Strong-inhibitor (0.5386) | Weak-inhibitor (0.6930) | Weak-inhibitor (0.5693) | Weak-inhibitor (0.6698) | Weak-inhibitor (0.6194) | Weak-inhibitor (0.6544) |
Acute Oral Toxicity | III | III | III | III | III | III |
Rat Acute Toxicity, LD50 (mol/Kg) | 3.0123 | 2.8808 | 2.8378 | 2.8435 | 2.8480 | 3.0139 |
Ki (at 298 K, nM) | 7.442 | 2.705 | 3.789 | 6.285 | 33.955 | 1.631 |