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Table 1 Clinical data from anesthetized animals (propofol Lipuro group) during the 20 h of anesthesia

From: In vivo study of hepatic oxidative stress and mitochondrial function in rabbits with severe hypotension after propofol prolonged infusion

Parameter	Time-point (h)
Parameter	T0	T3	T6	T9	T12	T15	T18	T20
pH	7.41 ± 0.03	7.39 ± 0.05	7.36 ± 0.05	7.36 ± 0.07	7.34 ± 0.03	7.33 ± 0.05	7.29 ± 0.06	7.26 ± 0.02
PaCO₂	35.6 ± 1.2	36.3 ± 2.1	37.0 ± 2.7	40.2 ± 0.9	39.7 ± 1.4	44.3 ± 1.7	45.1 ± 2.2	46.5 ± 1.8*
PaO₂	98.4 ± 5.6	109.9 ± 10.4	118.3 ± 12.6	134.1 ± 15.6	129.8 ± 22.8	111.4 ± 19.2	102.8 ± 13.6	96.4 ± 9.6
HCO₃ ⁻	20.6 ± 1.1	21.9 ± 2.3	21.2 ± 3.1	20.8 ± 3.3	19.9 ± 1.7	19.3 ± 2.4	18.6 ± 3.1	17.1 ± 1.6
HR	243.0 ± 18.2	210.6 ± 11.6	196.2 ± 10.2*	191.6 ± 19.5*	191.1 ± 15.2*	198.9 ± 16.1*	209.7 ± 14.1	237.7 ± 10.7
RR	56.5 ± 7.2	38 ± 8.6	32.3 ± 6.4	30.8 ± 5.3	29.6 ± 5.5	28.9 ± 3.7	26.4 ± 4.4	21.7 ± 4.1*
SABP	101.4 ± 4.9	88.1 ± 10.4	78.4 ± 17.1	66.5 ± 7.5	60.7 ± 14.2*	64.6 ± 16.4	48.7 ± 14.2*	47.4 ± 9.3*
DABP	71.9 ± 8.5	66.4 ± 8.7	55.7 ± 14.1	37.1 ± 10.2*	36.4 ± 9.7*	37.7 ± 8.6*	29.4 ± 4.5*	25.1 ± 5.6*
MABP	69.4 ± 10.8	64.7 ± 8.6	56.6 ± 12.2	40.1 ± 17.4	42.0 ± 13.1	39.7 ± 11.4*	36.7 ± 9.6*	34.0 ± 7.3*
SpO₂	97.7 ± 2.5	98.2 ± 3.7	95,6 ± 3.9	94.4 ± 4.1	93.4 ± 4.7	90.1 ± 1.8	89.4 ± 1.4	86.3 ± 2.8
T °C	38.1 ± 0.6	38.3 ± 0.8	37.9 ± 1.2	37.9 ± 0.7	37.6 ± 0.8	37.8 ± 0.5	37.2 ± 0.6	37.2 ± 0.2
IoC	88.3 ± 1.1	81.9 ± 8.6	76.5 ± 5.2	70.6 ± 7.2	69.7 ± 5.5	67.3 ± 5.8	65.0 ± 4.1*	62.2 ± 4.3*

Mean ± SD, n = 7; * p < 0.05 when compared with time before anesthesia (0 h)
PaCO ₂ partial pressure of carbon dioxide, PaO ₂ partial pressure of oxygen, SABP systolic arterial blood pressure, DABP diastolic arterial blood pressure, MABP mean arterial blood pressure are expressed in mmHg, cHCO ⁻₃ bicarbonate ion concentration in mmol/L, HR heart rate in beats per minute, RR respiratory rate in movements per minute, SpO ₂ peripheral oxygen saturation in %, T temperature in °C, IoC index of consciousness

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