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Table 1 Clinical data from anesthetized animals (propofol Lipuro group) during the 20 h of anesthesia

From: In vivo study of hepatic oxidative stress and mitochondrial function in rabbits with severe hypotension after propofol prolonged infusion

Parameter Time-point (h)
T0 T3 T6 T9 T12 T15 T18 T20
pH 7.41 ± 0.03 7.39 ± 0.05 7.36 ± 0.05 7.36 ± 0.07 7.34 ± 0.03 7.33 ± 0.05 7.29 ± 0.06 7.26 ± 0.02
PaCO2 35.6 ± 1.2 36.3 ± 2.1 37.0 ± 2.7 40.2 ± 0.9 39.7 ± 1.4 44.3 ± 1.7 45.1 ± 2.2 46.5 ± 1.8*
PaO2 98.4 ± 5.6 109.9 ± 10.4 118.3 ± 12.6 134.1 ± 15.6 129.8 ± 22.8 111.4 ± 19.2 102.8 ± 13.6 96.4 ± 9.6
HCO3 20.6 ± 1.1 21.9 ± 2.3 21.2 ± 3.1 20.8 ± 3.3 19.9 ± 1.7 19.3 ± 2.4 18.6 ± 3.1 17.1 ± 1.6
HR 243.0 ± 18.2 210.6 ± 11.6 196.2 ± 10.2* 191.6 ± 19.5* 191.1 ± 15.2* 198.9 ± 16.1* 209.7 ± 14.1 237.7 ± 10.7
RR 56.5 ± 7.2 38 ± 8.6 32.3 ± 6.4 30.8 ± 5.3 29.6 ± 5.5 28.9 ± 3.7 26.4 ± 4.4 21.7 ± 4.1*
SABP 101.4 ± 4.9 88.1 ± 10.4 78.4 ± 17.1 66.5 ± 7.5 60.7 ± 14.2* 64.6 ± 16.4 48.7 ± 14.2* 47.4 ± 9.3*
DABP 71.9 ± 8.5 66.4 ± 8.7 55.7 ± 14.1 37.1 ± 10.2* 36.4 ± 9.7* 37.7 ± 8.6* 29.4 ± 4.5* 25.1 ± 5.6*
MABP 69.4 ± 10.8 64.7 ± 8.6 56.6 ± 12.2 40.1 ± 17.4 42.0 ± 13.1 39.7 ± 11.4* 36.7 ± 9.6* 34.0 ± 7.3*
SpO2 97.7 ± 2.5 98.2 ± 3.7 95,6 ± 3.9 94.4 ± 4.1 93.4 ± 4.7 90.1 ± 1.8 89.4 ± 1.4 86.3 ± 2.8
T °C 38.1 ± 0.6 38.3 ± 0.8 37.9 ± 1.2 37.9 ± 0.7 37.6 ± 0.8 37.8 ± 0.5 37.2 ± 0.6 37.2 ± 0.2
IoC 88.3 ± 1.1 81.9 ± 8.6 76.5 ± 5.2 70.6 ± 7.2 69.7 ± 5.5 67.3 ± 5.8 65.0 ± 4.1* 62.2 ± 4.3*
  1. Mean ± SD, n = 7; * p < 0.05 when compared with time before anesthesia (0 h)
  2. PaCO 2 partial pressure of carbon dioxide, PaO 2 partial pressure of oxygen, SABP systolic arterial blood pressure, DABP diastolic arterial blood pressure, MABP mean arterial blood pressure are expressed in mmHg, cHCO 3 bicarbonate ion concentration in mmol/L, HR heart rate in beats per minute, RR respiratory rate in movements per minute, SpO 2 peripheral oxygen saturation in %, T temperature in °C, IoC index of consciousness