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Table 1 Costs and resource use assumptions

From: Cost impact of a non-invasive, portable device for patient self-administration of chronic migraine in a UK National Health Service setting

Variable Individual scenario Time-derived Definition Source
Administration costs Botox initial cycle £513.60 £70.00 Spire: Treatment (£650 incl. follow-up visits and drug) + initial adminstration (£140) − drug costs/Time-based: Consultant visit lasts 30 min plus 15 min nurse time http://www.spirehealthcare.com/hull/news/botox-for-migraine-treatment/. Accessed 14/02/2016, PSSRU, unit costs of health and social care 2014 (Curtis 2014)
Administration costs Botox every 12 weeks £373.60 £60.00 Spire Hull: Treatment (£650, incl. follow-up visits and drug) - drug costs/Time-based: Consultant visit lasts 15 min plus 15 min nurse time http://www.spirehealthcare.com/hull/news/botox-for-migraine-treatment/. Accessed 14/02/2016, PSSRU, unit costs of health and social care 2014 (Curtis 2014),
Botox drug costs per 12 weeks cycle £276.40 £276.40 Drug costs NICE Botox appraisal
Botox drug costs for 48 week cycle £276.40 £276.40 Drug costs NICE Botox appraisal
Administration costs TMS in initial quarter £140.00 £35.00 Spire Hull: Initial consultation fee £140/Time-based: Consultant visit lasts 15 min http://www.spirehealthcare.com/hull/news/botox-for-migraine-treatment/. Accessed 14/02/2016; PSSRU (Curtis 2014), Personal communication Hull
Administration costs TMS in follow-up quarter 0 0 Device used at home by patient  
Costs TMS in initial quarter responder 0 0 Not applied due to risk share approach Manufacturer
Costs TMS in follow-up quarter responder £450.00 £450.00 Current sTMS costs Manufacturer
Costs 1 GP Visit £45.63 £45.63 Surgery consultation last 11.7 min £3.90 per min (with qualification costs) incl. direct staff (Table 10.8b) PSSRU, unit costs of health and social care 2014 (Curtis 2014)
Costs hospital inpatient stay migraine £514.00 £514.00 NHS 2013/14 National Tariff—Patients continuing on Botox and TMS were assumed to be in need for furhter neurologists visits; PA04B applied for dicontinuing https://www.gov.uk/government/collections/payment-by-results-2013-14. Accessed 14/02/2016
Costs neurologist visit £128.00 £128.00 National tariff information spreadsheet-index: Neurology and Neurosurgery outpatient attendances https://www.gov.uk/government/collections/payment-by-results-2013-14. Accessed 14/02/2016
Costs emergency department visit £78.00 £78.00 National Tariff—VB09Z https://www.gov.uk/government/collections/payment-by-results-2013-14. Accessed 14/02/2016
Costs Triptan use per attack £1.08 £1.08 Weighted average for the mean cost of 1 triptan tablet in NHS England 2014 http://www.hscic.gov.uk/catalogue/PUB17274/pres-cost-anal-eng-2014-rep.pdf and Botox appraisal 2011
Number of A&E events per quarter 0.51 0.51 UK specific data from IBMS, Table 3 Bloudek et al. (2012)
Number of GP visits for migraine per quarter 1.44 1.44 UK specific data from IBMS, Table 3 Bloudek et al. (2012) and Blumenfeld et al. (2011)
Number of hospital inpatient stays per quarter 0.09 0.09 UK specific data from IBMS, Table 3 Bloudek et al. (2012)
Number of neurologists visit per quarter 0.43 0.43 UK specific data from IBMS, Table 3 Bloudek et al. (2012)
Number of Triptans used per quarter 7.29 7.29 7.29 triptans used for patients more than 15 attacks NICE Botox Appraisal (2011): Table 6.17 page 160
Probability Botox continuation 45.5 % 45.5 % Responder after cycle 2 based on Khalil et al. (2015b) Khalil et al. (2015b)
Probability TMS continuation 53.7 % 53.7 % Discontinuer minus those discontinuing due to lack of funding Bhola et al. (2015)
Botox resource use reduction per responder 12 weeks 49.7 % 49.7 % Observed reduction rate in observational trial Rothrock (2011), Table 3
TMS resource use reduction per responder quarter 46.7 % 46.7 % Observed reduction rate in observational trial Bhola et al. (2015), Table 3