Fig. 2
From: The dynamics of mucosal-associated invariant T cells in multiple sclerosis
Effects of FTY720 on MAITs. Upper panel The frequency of MAITs post FTY720 treatment. The frequency of MAITs (Vα7.2+ CD161hi cells) relative to total T cells (CD3+ cells) in the blood from subjects before (UT(pre)) and after FTY720-treatment (3 months, 1, 2 and 3 years; n = 7) is shown. Each individual was followed up to 3 years. The data are analyzed with Friedman test (from UT (Pre) to 2 years) with Dunn’s multiple comparison test for all the possible combinations. Groups showing a difference are indicated with an asterisk (*P < 0.05; **P < 0.01). Lower panel: The effect of FTY720 on the subset frequency of MAITs. The percentage of DN, CD8hi, and CD4 MAITs relative to total MAITs in blood from untreated subjects (UT, n = 15) and FTY720-treated (n = 7) subjects are shown. 3 months, 1, 2, and 3 years; subjects received FTY720 for 3 months, 1, 2, and 3 years, respectively. Data are analyzed with Kruskal–Wallis test with Dunn’s multiple comparison test for all the possible combinations. Groups showing a difference are indicated with an asterisk (*P < 0.05; **P < 0.01). All data are presented as horizontal lines: median; boxes: 25th percentile and 75th percentile; whiskers: minimum and maximum