Fig. 1
From: The dynamics of mucosal-associated invariant T cells in multiple sclerosis
CD8 MAITs consist of CD8hi and CD8hi/lo (DN) MAITs cells. a A representative FACS profile of mucosal-associated invariant T cells (MAITs) from a healthy donor (HD), a disease-modifying treatment free (untreated:UT) subject, and an FTY720-treated MS subject (MS/FTY720). MAITs are identified as cells harboring Vα7.2 and CD161 in CD3+ T cells. Vα7.2+ CD161hi cells were gated, and the expression levels of CD4 and CD8 were analyzed. The number in the figure shows the percentage of the indicated populations. b Difference in the relative frequency of MAIT cell subsets between HDs and untreated subjects. Relative frequency of total MAITs (Vα7.2+ CD161hi cells in the total CD3+ cells) from HDs (n = 10) and that from untreated subjects (UT, n = 15) are plotted (total). Relative frequency of DN MAITs, CD8hi MAITs, and CD4 MAITs in total MAITs are plotted (DN, CD8hi, and CD4, respectively). c The effect of INFβ on the frequency of MAITs. Relative frequency of total MAITs and that of the MAIT cell subset in total MAITs from UT (n = 15) and from INFβ-treated subjects (n = 12) are plotted (total, DN, CD8hi, and CD4, respectively). b, c All data are presented as horizontal lines: median; boxes: 25th percentile and 75th percentile; whiskers: minimum and maximum. P values after Mann–Whitney U test are shown