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Table 1 Characteristics of included studies

From: Intraoperative mechanical ventilation strategies in patients undergoing one-lung ventilation: a meta-analysis

Author

Year

No. of patients

Study intervention

Details of V T (ml/kg) and PEEP (cmH2O)

Age (year), mean (SD)

Type of surgery

Duration of one-lung ventilation in each mode (min), mean (SD)

Outcomes

Time point of measurement of outcomes

Preoperative FEV1 (% of predicted) (SD)

Randomized parallel study

Hu et al.

2014

(1) 15

(2) 15

(1) PCV-VG

(2) VCV

(1) V T = 7 PEEP = 0

(2) V T = 7 PEEP = 0

(1) 61 (6)

(2) 62 (7)

VATS

(1) 147(22)

(2) 154(52)

Respiratory parameters, gas exchange, hemodynamics

15 and 60 min after OLV

Not reported

Qutubet al.

2014

(1) 13

(2) 13

(3) 13

(1) PV 4

(2) PV 6

(3) CV

(1) V T = 4 PEEP = 5

(2) V T = 6 PEEP = 5

(3) V T = 8 PEEP = 5

(1) 42 (32–54)

(2) 39.5 (31–51)

(3) 36 (29–48)

VATS

Not reported

Extravascular lung water content index, respiratory parameters, gas exchange, clinical outcomes

15, 45 min after OLV; 48 h, 30d post operation

(1) 87.1 (3.0)

(2) 88.4 (2.9)

(3) 85.8 (4.1)

Jung et al.

2014

(1) 30

(2) 30

(1) PV

(2) CV

(1) V T = 6 PEEP = 8

(2) V T = 10 PEEP = 0

(1) 35.2 (10.2)

(2) 36.3 (9.5)

VATS

Not reported

Respiratory parameters

5, 15, 30, 45 min after OLV

Not reported

Shen et al.

2013

(1) 53

(2) 48

(1) PV

(2) CV

(1) V T = 5 PEEP = 5

(2) V T = 8 PEEP = 0

(1) 60.5 (7.3)

(2) 57.2 (9.1)

MIE

(1) 72.2 (23.6)

(2) 75.0 (18.8)

Clinical outcomes, gas exchange, cytokines expression

18 h post operation, 30d post operation

(1) 92.8 (14.6)

(2) 87.1 (16.9)

Maslow et al.

2013

(1) 16

(2) 16

(1) PV

(2) CV

(1) V T = 5 PEEP = 5

(2) V T = 10 PEEP = 0

(1) 62 (14.4)

(2) 69.6 (12.9)

Thoracic surgery

(1) 42 (8.3)

(2) 46 (9.5)

Respiratory parameters, gas exchange, hemodynamics, clinical outcomes

5, 10, 15, 20, 30 min after OLV

(1) 85.8 (21.7)

(2) 75.4 (16.4)

Ye and Li

2011

(1) 10

(2) 10

(3) 10

(1) PCV

(2) VCV

(3) PV

(1) V T = 8 PEEP = 0

(2) V T = 8 PEEP = 0

(3) V T = 6 PEEP = 5

20–65

Thoracic surgery

Not reported

Respiratory parameters, gas exchange

20, 45 and 70 min after OLV

Not reported

Yang et al.

2011

(1) 50

(2) 50

(1) PV

(2) CV

(1) V T = 6 PEEP = 5

(2) V T = 10 PEEP = 0

(1) 58 (12)

(2) 60 (10)

Thoracic surgery

(1) 120 (41)

(2) 126 (53)

Clinical outcomes, gas exchange, hemodynamics

15, 60 min after OLV; 2, 72 h post operation

(1) 105 (9)

(2) 104 (17)

Boules and Ghobrial

2011

(1) 18

(2) 19

(1) PCV-VG

(2) VCV

(1) V T = 6 PEEP = 0

(2) V T = 6 PEEP = 0

(1) 33.4 (6.4)

(2) 34.7 (7.6)

Thoracic surgery

(1) 88.7 (42.1)

(2) 75.6 (34.7)

Respiratory parameters, gas exchange, hemodynamics, clinical outcomes

30 min after OLV;72 h post operation

(1) 73.4 (11.7)

(2) 74.3 (12.5)

Pardos et al.

2009

(1) 55

(2) 55

(1) PCV +PEEP

(2) VCV + PEEP

(1) V T = 8 PEEP = 0; 20 min after OLV PEEP = 5

(2) V T = 8 PEEP = 0; 20 min after OLV PEEP = 5

(1) 59.5 (13)

(2) 63.9 (11)

Thoracic surgery

Not reported

Respiratory parameters, gas exchange, clinical outcomes

20, 30 and 40 min after OLV; 24 h post operation; 30d post operation

(1) 91.2 (24)

(2) 87.9 (21)

Lin et al.

2008

(1) 20

(2) 20

(1) PV

(2) CV

(1) V T = 5–6 PEEP = 3–5

(2) V T = 10 PEEP unclear

(1) 55

(2) 54

Thoracic surgery

Not reported

Cytokines expression, respiratory parameters, gas exchange

120 min after OLV, 24 h post operation

Not reported

Michelet et al.

2006

(1) 26

(2) 26

(1) PV

(2) CV

(1) V T = 5 PEEP = 5

(2) V T = 9 PEEP = 0

(1) 61 (10)

(2) 60 (8.5)

Thoracic surgery

(1) 85 (29)

(2) 89 (29)

Cytokines expression, respiratory parameters, gas exchange, clinical outcomes

15 min after OLV; at the end of OLV; 1,18 h post operation

(1) 93 (19)

(2) 96 (18)

Randomized cross-over study

Song et al.

2014

27

(1) PCV-VG

(2) VCV

(1) V T = 8 PEEP = 0

(2) V T = 8 PEEP = 0

63.6 (9.7)

Thoracic surgery

(1) 30

(2) 30

Respiratory parameters, gas exchange, hemodynamics

30 min after OLV in each mode

107.3 (33.1)

Pu et al.

2014

20

(1) PCV-VG

(2) VCV

(1) V T = 8–10 PEEP unclear

(2) V T = 8–10 PEEP unclear

59.8 (unclear)

Thoracic surgery

(1) 30

(2) 30

Respiratory parameters, gas exchange, hemodynamics

30 min after OLV in each mode

Not reported

Al Shehri et al.

2014

28

(1) PCV

(2)VCV

(1) V T = 6 PEEP = 5

(2) V T = 6 PEEP = 5

(1) 37.4 (11.51)

(2) 39.1 (13.93)

Thoracic surgery

(1) 30

(2) 30

Right ventricular function, gas exchange, hemodynamics

30 min after OLV in each mode

84.5 (10.8)

Végh et al.

2013

100

(1) PV

(2) CV

(1) V T = 5 PEEP = 5

(2) V T = 10 PEEP = 0

(1) 64 (12)

(2) 63 (12)

Thoracic surgery

(1) 30

(2) 30

Respiratory parameters, gas exchange, hemodynamics

30 min after OLV in each mode

91.5

(14.0)

Roze et al.

2012

82

(1) PV

(2) CV

(1) V T = 5 PEEP = 9 (1)

(2) V T = 8 PEEP = 5

(1) 62 (10)

(2) 60 (10)

Thoracic surgery

(1) 10

(2) 10

Respiratory parameters, Gas exchange, hemodynamics

10 min after OLV in each mode

Not reported

Sungur Ulke et al.

2011

31

(1) PV

(2) CV

(1) V T = 6

PEEP = 5

(2) V T = 8 PEEP = 0

58.3 (7.2)

Thoracic surgery

(1) 20

(2) 20

Respiratory parameters, gas exchange, hemodynamics

20 min after OLV in each mode

75 (14.7)

Montes et al.

2010

41

(1) PCV

(2)VCV

(1) V T = 6 PEEP = 5

(2) V T = 6 PEEP = 5

(1) 59.1 (16)

(2) 56.1 (17)

Thoracic surgery

(1) 30

(2) 30

Respiratory parameters, gas exchange

30 min after OLV in each mode

91.2 (19.3)

Choi et al.

2009

18

(1) PCV

(2) VCV

(1) V T = 8 PEEP = 0

(2) V T = 9 PEEP = 0

61.4 (10.3)

Robot-assisted esophagectomy

(1) 30

(2) 30

Respiratory parameters, gas exchange, hemodynamics

30 min after OLV in each mode

109.1 (21.2)

Unzueta et al.

2007

57

(1) PCV

(2) VCV

(1) V T = 9 PEEP = 0

(2) V T = 9 PEEP = 0

(1) 58.25 (15.15) (2) 54.75 (13.91)

Thoracic surgery

(1) 30

(2) 30

Respiratory parameters, gas exchange

30 min after OLV in each mode

82.2 (17.5)

Tugrul et al.

1997

48

(1) PCV

(2) VCV

(1) V T = 10 PEEP unclear

(2) V T = 10 PEEP unclear

56.4

Thoracic surgery

(1) 30

(2) 30

Respiratory parameters, gas exchange, hemodynamics

30 min after OLV in each mode

76.8 (14)

  1. ARS alveolar recruitment strategy, CV conventional ventilation, MIE minimally invasive esophagectomy, PCV pressure-controlled ventilation, PCV-VG volume guaranteed pressure-controlled ventilation, PV protective ventilation, VATS video-assisted thoracoscopic surgery, VCV volume-controlled ventilation
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