|
Factor
|
Group
|
Treatment
|
P value
|
|---|
|
No-AZM
|
AZM
|
|---|
|
N
| |
96
|
29
| |
|
Age (years)
| |
76.5 [67, 82.25]
|
70 [65, 81]
|
0.35
|
|
Sex
|
M/F
|
66 (68.8)/30 (31.2)
|
19 (65.5)/10 (34.5)
|
0.821
|
|
Cirrhosis
|
Yes
|
10 (10.4)
|
3 (10.3)
|
1
|
|
Sepsis
|
pulmonary
|
55 (57.3)
|
23 (79.3)
|
0.048
|
|
Nonpulmonary
|
41 (42.7)
|
6 (20.7)
|
|
APACHE.II
| |
23 [18, 26]
|
24 [21, 27]
|
0.462
|
|
McCabe
|
1/2/3
|
88 (91.7)/3 (3.1)/5 (5.2)
|
26 (89.7)/2 (6.9)/1 (3.4)
|
0.63
|
|
ARDS severity
|
Mild
|
5 (5.2)
|
5 (17.2)
|
0.113
|
|
Moderate
|
45 (46.9)
|
13 (44.8)
|
|
Severe
|
46 (47.9)
|
11 (37.9)
|
|
SOFA
| |
7 [5, 11]
|
9 [7, 12]
|
0.143
|
|
PaO2/FiO2
| |
100.45 [70.97, 132.70]
|
114.20 [84.50, 180.00]
|
0.045
|
|
CT.score
| |
214.05 [184.80, 265.60]
|
211.70 [188.10, 268.50]
|
0.667
|
|
Alb, g/dL
| |
2.90 [2.58, 3.30]
|
2.50 [2.20, 3.00]
|
0.002
|
|
WBC
| |
10,450 [5250, 14,400]
|
7300 [2300, 12,200]
|
0.055
|
|
C-reactive protein, mg/dL
| |
15.33 [8.68, 25.07]
|
19.69 [10.22, 30.10]
|
0.239
|
|
Lactate dehydrogenase, IU/L
| |
312 [248.25, 436.50]
|
301 [233.00, 434.00]
|
0.621
|
|
DIC score
| |
2 [2, 4]
|
4 [2, 5]
|
0.028
|
|
FDP, mg/L
| |
11.00 [6.72, 18.10]
|
11.90 [9.30, 20.00]
|
0.382
|
|
AntithrombinIII, %
| |
66.50 [52.75, 81.25]
|
65.00 [51.00, 79.00]
|
0.527
|
|
PLT,X104
| |
18.35 [11.93, 28.30]
|
12.40 [7.70, 18.40]
|
0.003
|
|
D.dimer.μg/ml
| |
5.95 [2.48, 11.00]
|
4.60 [3.10, 9.30]
|
0.398
|
|
Death (%)
| |
48 (50.0)
|
10 (34.5)
|
0.202
|
- n (%), median [IQR]
-
APACHE acute physiology and chronic health evaluation, ARDS acute respiratory distress syndrome, AZM azithromycin, DIC disseminated intravascular coagulation, FDP fibrin/fibrinogen degradation products, SOFA Sequential Organ Failure Assessment score
