Table 2 Summary of study characteristics
| Studies | Design | Prostheses | Country | Center | No (CDA/ACDF) | Age(CDA/ACDF) | Male % (CDA/ACDF) | Follow up (%) |
|---|---|---|---|---|---|---|---|---|
| Zhang et al. (2012) | RCT | Bryan (Medtronic Sofamor Danek, Memphis, TN, USA) | China | Multicenter |
120 60/60 | 44.8/45.6 | 58.3/53.3 | NA |
| Sasso et al. (2007, 2008, 2011), Heller et al. (2009), Riew et al. (2008) | RCT | Bryan (Medtronic Sofamor Danek, Memphis, TN, USA) | USA | Multicenter |
463 242/221 | 44.4/44.7 | 45.5/55.1 | 73 |
| RCT | Bryan (Medtronic Sofamor Danek, Memphis, TN, USA) | USA | Multicenter |
199 106/93 | 44.5/44.4 | 17.0/16.1 | NA | |
| Cheng et al. (2009, 2011) | RCT | Bryan (Medtronic Sofamor Danek, Memphis, TN, USA) | USA | Singlecenter |
83 41/42 | 47.2/47.7 | 51.2/54.8 | 98 |
| Skeppholm et al. (2015) | RCT | Discover (DePuy Spine, Raynham, MA, USA) | Sweden | Multicenter |
153 73/80 | 42.2/41.7 | 49.4//47.1 | 91 |
| Rozankovic et al. (2014) | RCT | Discover (DePuy Spine, Raynham, MA, USA) | Croatia | Singlecenter |
101 51/50 | 41/41 | 49.0/50.0 | 100 |
| Qizhi et al. (2014) | RCT | Discover (DePuy Spine, Raynham, MA, USA) | China | Singlecenter |
30 14/16 | 47/48 | 64.2/68.8 | 100 |
| Coric et al. (2011) | RCT | Kineflex (Spinal Motion Inc, Mountain View, CA, USA) | USA | Multicenter |
269 136/133 | 43.7/43.9 | 37.5/44/4 | 87 |
| Zhang et al. (2014) | RCT | Mobi-C (LDR Medical, Troyes, France) | USA | Multicenter |
111 55/56 | 44.8/46.7 | 45.5/46.4 | NA |
| Hisey et al. (2014, 2015) | RCT | Mobi-C (LDR Medical, Troyes, France) | USA | Multicenter |
245 164/81 | 43/44 | 47.6/44.4 | 75 |
| Davis et al. (2013, 2015) | RCT | Mobi-C (LDR Medical, Troyes, France) | USA | Multicenter |
330 225/105 | 45.3/46.2 | 50.2/42.9 | 86 |
| Phillips et al. (2013, 2015) | RCT | PCM (NuVasive Inc, San Diego, CA, USA) | USA | Multicenter |
293 163/130 | 45.3/43.7 | 52.8/51.9 | 72.70 |
| McAfee et al. (2010) | RCT | PCM (NuVasive Inc, San Diego, CA, USA) | USA | Multicenter |
251 151/100 | 45/44 | 50.3/47.0 | NA |
| Riina et al. (2008) | RCT | Prestige ST (Medtronic Sofamor Danek, Memphis, TN, USA) | USA | Singlecenter |
19 10.0/9.0 | 40.8/38.1 | 20.0/33.3 | 84.20 |
| Riew et al. (2008) | RCT | Prestige ST (Medtronic Sofamor Danek, Memphis, TN, USA) | USA | Multicenter |
111 59/52 | 43.4/46.0 | 49.2/40.4 | NA |
| Porchet and Metcalf (2004) | RCT | Prestige II (Medtronic Sofamor Danek, Memphis, TN, USA) | Switzerland | Multicenter |
55 27/28 | 44.3/43.2 | 63.0/40.4 | 67.3 |
| Mummaneni et al. (2007), Burkus et al. (2010, 2014) | RCT | Prestige ST (Medtronic Sofamor Danek, Memphis, TN, USA) | USA | Multicenter |
541 276/265 | 43.3/43/9 | 46.4/46 | 77.80 |
| Nabhan et al. (2007a, b, c, 2011) | RCT | ProDisc-C (Synthes Inc, West Chester, PA,USA) | Germany | Singlecenter |
41 20/21 | 44 | 23/18 | NA |
| Murrey et al. (2008, 2009), Delamarter et al. (2010), Kelly et al. (2011), Kesman et al. (2012), Zigler et al. (2013), Delamarter and Zigler (2013) | RCT | ProDisc-C (Synthes Inc, West Chester, PA,USA) | USA | Multicenter |
209 103/106 | 42.1/43/5 | 44.7/46.2 | 95.20 |
| Vaccaro et al. (2013) | RCT | SECURE-C (Globus Medical, Audubon, PA, USA) | USA | Multicenter |
380 236/144 | 43.4/44.4 | 53.6/48.6 | 87.10 |