Table 3 Prevalence of KRAS and GNAS mutations in patients with IPMN according to the ethnicity, mutation detection, and specimen type
Category | KRAS mutation | GNAS mutation | ||||||
|---|---|---|---|---|---|---|---|---|
No. of studies | No. of cases | Prevalence (%) (95Â % CI) | P value | No. of studies | No. of cases | Prevalence (%) (95Â % CI) | P value | |
Overall | 33 | 1253 | 60.9 (54.3–67.1) |  | 11 | 835 | 55.8 (48.5–62.8) |  |
Ethnicity | Â | Â | Â | 0.106 | Â | Â | Â | 0.429 |
 Caucasian | 15 | 532 | 55.1 (45.2–64.7) |  | 7 | 374 | 58.4 (48.8–67.4) |  |
 Asian | 18 | 721 | 66.0 (56.9–74.0) |  | 4 | 461 | 52.6 (41.8–63.1) |  |
Detection method | Â | Â | Â | 0.207 | Â | Â | Â | 0.552 |
 Sequencing | 27 | 1017 | 59.0 (52.1–65.6) |  | 9 | 694 | 54.9 (47.0–62.5) |  |
 Non-sequencing | 6 | 236 | 69.0 (54.6–80.4) |  | 2 | 141 | 60.9 (42.3–76.9) |  |
Specimen typea | Â | Â | Â | 0.095 | Â | Â | Â | 0.147 |
 Tissue | 27 | 929 | 58.9 (51.3–66.1) |  | 8 | 533 | 61.0 (52.0–69.4) |  |
 Cyst fluid or pancreatic juice | 8 | 324 | 71.4 (58.4–81.7) |  | 5 | 302 | 50.3 (39.1–61.5) |  |