KRAS, GNAS, and RNF43 mutations in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis

Lee, Ju-Han; Kim, Younghye; Choi, Jung-Woo; Kim, Young-Sik

doi:10.1186/s40064-016-2847-4

SpringerPlus

Table 1 Characteristics of individual studies of KRAS mutation in patients with intraductal papillary mucinous neoplasm

From: KRAS, GNAS, and RNF43 mutations in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis

Study	Country	Ethnicity	Detection method	Specimen	KRAS mutation (%)
Amato E	Italy	Caucasian	Sequencing	Tissue	24/48 (50.0)
Chadwick B	USA	Caucasian	Sequencing	Tissue	37/52 (71.2)
Chang X	China	Asian	Sequencing	Tissue	9/16 (56.3)
Fritz S	USA	Caucasian	Sequencing	Tissue	8/20 (40.0)
Furukawa T	Japan	Asian	ASH, sequencing	Tissue	5/6 (83.3)
Hosoda W	Japan	Asian	real-time PCR, sequencing	Tissue	59/91 (64.8)
Ideno N	Japan	Asian	HRM, sequencing	Tissue	75/95 (78.9)
Jang JY	Korea	Asian	Sequencing	Tissue	13/37 (35.1)
Kaino M	Japan	Asian	SSCP, sequencing	Pancreatic juice	12/12 (100.0)
Kitago M	Japan	Asian	Sequencing	Tissue	16/20 (80.0)
Kobayashi N	Japan	Asian	PCR/PHFA	Pancreatic juice	13/22 (59.1)
Kondo H	Japan	Asian	SSCP, sequencing	Pancreatic juice	12/13 (92.3)
Kuboki Y	Japan	Asian	Sequencing	Tissue	96/172 (55.8)
Lee LS	USA	Caucasian	Sequencing	Tissue	9/19 (47.4)
Lubezky N	Israel	Caucasian	Sequencing	Tissue	9/27 (33.3)
Mizuno O	Japan	Asian	Semiquantitative PCR	Pancreatic juice	43/53 (81.1)
Mohri D	Japan	Asian	Sequencing	Tissue	14/25 (56.0)
Muller J	Germany	Caucasian	PCR–RFLP	Tissue	4/13 (30.8)
Mulligan NJ	USA	Caucasian	PCR	Tissue	5/7 (71.4)
Nakata B	Japan	Asian	SSCP, sequencing	Tissue	19/26 (73.1)
Paal E	USA	Caucasian	Sequencing	Tissue	2/15 (13.3)
Raimondo M	USA	Caucasian	SSCP, sequencing	Tissue	29/40 (72.5)
Schönleben F	USA	Caucasian	Sequencing	Tissue	17/36 (47.2)
Sessa F	Italy	Caucasian	SSCP, sequencing	Tissue	8/26 (30.8)
Siddiqui AA	USA	Caucasian	Quantitative PCR	Cyst fluid	6/9 (66.7)
Singhi AD	USA	Caucasian	Sequencing	Cyst fluid	35/50 (70.0)
Tada M	Japan	Asian	Sequencing	Tissue	3/5 (60.0)
Takano S	Japan	Asian	Sequencing	Tissue	6/6 (100.0)
				Pancreatic juice	32/50 (64.0)
Tan MC	USA	Caucasian	Sequencing	Tissue	27/38 (71.1)
Uemura K	Japan	Asian	Sequencing	Tissue	8/10 (80.0)
Wada K	Japan	Asian	Sequencing	Tissue	15/23 (65.2)
Wu J	USA	Caucasian	PCR/ligation	Tissue	39/49 (79.6)
				Cyst fluid	68/83 (81.9)
Yoshizawa K	Japan	Asian	Sequencing	Tissue	4/7 (57.1)

ASH allele-specific oligonucleotide hybridization, PCR polymerase chain reaction, HRM high-resolution melt-curve analysis, SSCP single strand conformation polymorphism, PHFA preferential homoduplex formation assay, RFLP restriction fragment length polymorphism

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