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Table 1 Characteristics of individual studies of KRAS mutation in patients with intraductal papillary mucinous neoplasm

From: KRAS, GNAS, and RNF43 mutations in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis

Study Country Ethnicity Detection method Specimen KRAS mutation (%)
Amato E Italy Caucasian Sequencing Tissue 24/48 (50.0)
Chadwick B USA Caucasian Sequencing Tissue 37/52 (71.2)
Chang X China Asian Sequencing Tissue 9/16 (56.3)
Fritz S USA Caucasian Sequencing Tissue 8/20 (40.0)
Furukawa T Japan Asian ASH, sequencing Tissue 5/6 (83.3)
Hosoda W Japan Asian real-time PCR, sequencing Tissue 59/91 (64.8)
Ideno N Japan Asian HRM, sequencing Tissue 75/95 (78.9)
Jang JY Korea Asian Sequencing Tissue 13/37 (35.1)
Kaino M Japan Asian SSCP, sequencing Pancreatic juice 12/12 (100.0)
Kitago M Japan Asian Sequencing Tissue 16/20 (80.0)
Kobayashi N Japan Asian PCR/PHFA Pancreatic juice 13/22 (59.1)
Kondo H Japan Asian SSCP, sequencing Pancreatic juice 12/13 (92.3)
Kuboki Y Japan Asian Sequencing Tissue 96/172 (55.8)
Lee LS USA Caucasian Sequencing Tissue 9/19 (47.4)
Lubezky N Israel Caucasian Sequencing Tissue 9/27 (33.3)
Mizuno O Japan Asian Semiquantitative PCR Pancreatic juice 43/53 (81.1)
Mohri D Japan Asian Sequencing Tissue 14/25 (56.0)
Muller J Germany Caucasian PCR–RFLP Tissue 4/13 (30.8)
Mulligan NJ USA Caucasian PCR Tissue 5/7 (71.4)
Nakata B Japan Asian SSCP, sequencing Tissue 19/26 (73.1)
Paal E USA Caucasian Sequencing Tissue 2/15 (13.3)
Raimondo M USA Caucasian SSCP, sequencing Tissue 29/40 (72.5)
Schönleben F USA Caucasian Sequencing Tissue 17/36 (47.2)
Sessa F Italy Caucasian SSCP, sequencing Tissue 8/26 (30.8)
Siddiqui AA USA Caucasian Quantitative PCR Cyst fluid 6/9 (66.7)
Singhi AD USA Caucasian Sequencing Cyst fluid 35/50 (70.0)
Tada M Japan Asian Sequencing Tissue 3/5 (60.0)
Takano S Japan Asian Sequencing Tissue 6/6 (100.0)
     Pancreatic juice 32/50 (64.0)
Tan MC USA Caucasian Sequencing Tissue 27/38 (71.1)
Uemura K Japan Asian Sequencing Tissue 8/10 (80.0)
Wada K Japan Asian Sequencing Tissue 15/23 (65.2)
Wu J USA Caucasian PCR/ligation Tissue 39/49 (79.6)
     Cyst fluid 68/83 (81.9)
Yoshizawa K Japan Asian Sequencing Tissue 4/7 (57.1)
  1. ASH allele-specific oligonucleotide hybridization, PCR polymerase chain reaction, HRM high-resolution melt-curve analysis, SSCP single strand conformation polymorphism, PHFA preferential homoduplex formation assay, RFLP restriction fragment length polymorphism 
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