Clinicopathological and prognostic significance of heat shock protein 27 (HSP27) expression in non-small cell lung cancer: a systematic review and meta-analysis

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Table 3 Meta-analyses of the prognostic value of HSP27 expression in patients with NSCLC

Survival outcomes	N	No. samples			Heterogeneity (I-squared, p)	Model	HR (95 % CI)	P value	Conclusion
Survival outcomes	N	Total	PE	NE	Heterogeneity (I-squared, p)	Model	HR (95 % CI)	P value	Conclusion
1-year OS	2	140	98	42	91.5 %, 0.001	Random	0.885 (0.140–5.599)	0.896	Not significant
5-year OS	3	334	185	149	39.6 %, 0.191	Fixed	1.832 (1.322–2.538)	<0.001	Significant
10-year OS	Given up because of the scarcity of included studies

CI confidence interval, HR hazard ratio, HSP27 heat shock protein 27, N reference count, NE negative expression, NSCLC non-small cell lung cancer, OS overall survival, PE positive expression