Clinicopathological and prognostic significance of heat shock protein 27 (HSP27) expression in non-small cell lung cancer: a systematic review and meta-analysis

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Table 2 Meta-analysis of the clinicopathological significance of HSP27 expression in patients with NSCLC

Clinicopathological characteristics	N	No. samples			Heterogeneity (I-squared, p)	Model	OR with 95 % CI	P value	Conclusion
Clinicopathological characteristics	N	Total	PE	NE	Heterogeneity (I-squared, p)	Model	OR with 95 % CI	P value	Conclusion
Gender (male vs female)	7	654	383	271	48.8 %, 0.069	Random	1.099 (0.629–1.920)	0.740	Not significant
Age (≥60 years vs <60 years)	3	372	220	152	0.0 %, 0.570	Fixed	1.125 (0.637–1.986)	0.685	Not significant
Smoking status (yes vs no)	3	372	220	152	0.0 %, 0.434	Fixed	1.246 (0.812–1.913)	0.314	Not significant
Differentiation (G3 vs G1 and G2)	8	714	426	288	0.0 %, 0.644	Fixed	2.309 (1.645–3.242)	<0.001	Significant
Lymphatic metastasis (yes vs no)	8	714	426	288	50.8 %, 0.047	Random	1.425 (1.040–1.953)	0.027	Significant
TNM stage (III/IV vs I/II)	5	541	321	220	54.8 %, 0.065	Random	2.10 (1.134–3.888)	0.018	Significant
Histological types (SCC vs AC)	4	379	224	155	33.0 %, 0.214	Fixed	1.827 (1.171–2.849)	0.008	Significant
Tumor size (≥3 cm vs <3 cm)	2	259	138	121	0.0 %, 0.858	Fixed	1.949 (1.112–3.416)	0.020	Significant

AC adenocarcinoma, CI confidence interval, HSP27 heat shock protein 27, N reference count, NE negative expression, NSCLC non-small cell lung cancer, OR odds ratio, PE positive expression, SCC squamous cell carcinoma