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Table 2 Summary of randomized controlled trials of probiotics for the management of chronic constipation

From: Intestinal microbiota and chronic constipation

References Population Intervention Comparator Author’s conclusion
Tabbers et al. (2011) n = 159 (control n = 80, intervention n = 79) B. lactis DN-173 010 Acidified milk without probiotics Increased stool frequency, but not statistically significant compared with control group
Coccorullo et al. (2010) n = 44 (control n = 22, intervention n = 22) L. reuteri DSM 17938 Identical placebo Increased bowel frequency
Favretto et al. (2013) n = 30 (control n = 15, intervention n = 15) B. lactis Bi-07 Fresh cheese without probiotics Beneficial effects
Yang et al. (2008) n = 126 (control n = 63, intervention n = 63) B. lactis DN-173010 Acidified milk without probiotics Beneficial effects on stool frequency, defecation condition and stool consistency
Ishizuka et al. (2012) n = 17 (cross-over design) B. lactis GCL2505 Milk-like drink Beneficial effects
Waller et al. (2011) n = 100 (control n = 34, Intervention: high dose n = 33 low dose n = 33) B. lactis HN019 Capsules with rice maltodextrin Decreased whole gut transit time in a dose-dependent manner
Mazlyn et al. (2013) n = 90 (control n = 43, intervention n = 47) L. casei Shirota Fermented milk without probiotics Improvement in constipation severity
Riezzo et al. (2012) n = 20 (cross-over design) L. paracasei IMPC 2.1 Artichokes without probiotics Beneficial effects
Koebnick et al. (2003) n = 70 (control n = 35, intervention n = 35) L. casei shirota Beverage without probiotics Beneficial effects on self-reported severity of constipation and stool consistency