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Table 1 Summary of randomized controlled trials of prebiotics for the management of chronic constipation

From: Intestinal microbiota and chronic constipation

References

Subjects

Intervention

Comparator

Author’s conclusion

Linetzky Waitzberg et al. (2012)

Patients n = 60 (control n = 32, Intervention n = 28)

Inulin

Placebo

Decrease the amount of pathological bacteria of the Clostridium genera

Bouhnik et al. (2004)

Patients n = 65 (control n = 32, Intervention n = 33)

Lactulose

Polyethylene glycol

Beneficial effects, an increase in faecal bifidobacteria counts

Li et al. (2013)

Mice n = 40

Deshipu stachyose granules (DSG)

Placebo

Facilitating intestinal peristalsis and fecal excretion, increasing beneficial intestinal bacteria and inhibiting pathogenic bacteria

Li et al. (2011)

Rats n = 90

Prebiotics (a combination of GOS, XOS, OF and inulin)

Placebo

Beneficial effects on constipation