Fig. 4

Results of MTC analyses between ivermectin 1 % cream QD and comparators for the incidence of any adverse events (top), serious adverse events (middle), and treatment-related adverse events (bottom) at 12 weeks. Risk ratios evaluate the probability of success (relieving rosacea) when using ivermectin 1 % cream QD, compared to other comparator treatments. A risk ratio >1 demonstrates a greater likelihood of success using ivermectin 1 % cream QD, a risk ratio credible interval that does not cross 1 demonstrates a significant difference between ivermectin 1 % cream QD and the comparator (positive values indicate superiority, negative values indicate inferiority). The comparison of ivermectin 1 % cream QD demonstrated significantly better results compared with azelaic acid 15 % gel/foam BID for any adverse events and with vehicle and azelaic acid 15 % gel/foam BID for any treatment-related adverse events. No comparator demonstrated significantly better results compared with ivermectin 1 % cream QD. Studies contributing to any adverse events: nine studies (Gold et al. 2014a; Stein et al. 2014; Galderma 2006; Tan et al. 2002; Thiboutot et al. 2003, 2008; Torok et al. 2005; NCT00617903 2013), any serious adverse events: four studies (Gold et al. 2014a, b; Galderma 2006; Draelos et al. 2015), any treatment-related adverse events: seven studies (Gold et al. 2014a; Stein et al. 2014; Galderma 2006; Tan et al. 2002; Thiboutot et al. 2008; Torok et al. 2005; Draelos et al. 2013). MTC results are derived from a fixed effects model. AZA azelaic acid, bid twice daily, Crl credible interval, MET metronidazole, MTC mixed treatment comparison, QD once daily, RR risk ratio