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Table 3 Risk factors for cardiovascular disease in RA patients estimated by univariate and multivariate Cox proportional hazard regression model

From: Risk for cardiovascular disease in Japanese patients with rheumatoid arthritis: a large-scale epidemiological study using a healthcare database

  Univariate model Multivariate model
Hazard ratio (95 % CI) P value Hazard ratio (95 % CI) P value
Male 1.07 (0.76–1.51) 0.6812 1.02 (0.70–1.49) 0.8990
Age ≥65 years 8.50 (5.13–14.09) <0.0001 8.52 (4.76–15.23) <0.0001
CRP at baseline ≥1.0 mg/dl 2.00 (1.39–2.88) 0.0002 1.43 (0.99–2.07) 0.0564
Total cholesterol at baseline ≥220 mg/dla 0.68 (0.34–1.38) 0.2883
Diabetes complications 1.86 (0.98–3.54) 0.0577 1.72 (0.83–3.56) 0.1436
  1. RA rheumatoid arthritis, CRP C-reactive protein
  2. aTotal cholesterol at baseline was excluded from covariates in the multivariate model because there was no significant association between total cholesterol and CVD as well as a high proportion of missing data