Risk for cardiovascular disease in Japanese patients with rheumatoid arthritis: a large-scale epidemiological study using a healthcare database

SpringerPlus

Table 3 Risk factors for cardiovascular disease in RA patients estimated by univariate and multivariate Cox proportional hazard regression model

	Univariate model		Multivariate model
	Hazard ratio (95 % CI)	P value	Hazard ratio (95 % CI)	P value
Male	1.07 (0.76–1.51)	0.6812	1.02 (0.70–1.49)	0.8990
Age ≥65 years	8.50 (5.13–14.09)	<0.0001	8.52 (4.76–15.23)	<0.0001
CRP at baseline ≥1.0 mg/dl	2.00 (1.39–2.88)	0.0002	1.43 (0.99–2.07)	0.0564
Total cholesterol at baseline ≥220 mg/dl^a	0.68 (0.34–1.38)	0.2883	–	–
Diabetes complications	1.86 (0.98–3.54)	0.0577	1.72 (0.83–3.56)	0.1436

RA rheumatoid arthritis, CRP C-reactive protein
^aTotal cholesterol at baseline was excluded from covariates in the multivariate model because there was no significant association between total cholesterol and CVD as well as a high proportion of missing data