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Table 2 Incidence rate ratios of cardiovascular disease

From: Risk for cardiovascular disease in Japanese patients with rheumatoid arthritis: a large-scale epidemiological study using a healthcare database

 

RA patients (N = 8658)

OA patients (N = 32,202)

RA versus OA

Events

PYs at risk

Events

PYs at risk

Crude IRR (95 % CI)

Adjusted IRRa (95 % CI)

CVD (total)

673

10,946

1633

43,304

1.63 (1.49–1.78)

2.12 (1.93–2.32)

 Ischemic heart disease

260

11,280

586

44,091

1.73 (1.50–2.01)

2.16 (1.86–2.50)

  Myocardial infarction

53

11,481

71

44,574

2.90 (2.03–4.14)

3.62 (2.52–5.18)

  Angina pectoris

224

11,319

528

44,138

1.65 (1.41–1.93)

2.05 (1.75–2.40)

 Heart failure

358

11,234

808

44,003

1.74 (1.53–1.97)

2.34 (2.07–2.65)

 Stroke

177

11,396

513

44,286

1.34 (1.13–1.59)

1.68 (1.41–2.00)

  Cerebral infarction

136

11,433

431

44,327

1.22 (1.01–1.48)

1.56 (1.29–1.90)

  Intracerebral hemorrhage

32

11,506

77

44,599

1.61 (1.07–2.43)

1.85 (1.22–2.81)

  Subarachnoid hemorrhage

15

11,517

15

44,626

3.87 (1.89–7.93)

4.45 (2.13–9.26)

  1. RA rheumatoid arthritis, OA osteoarthritis, PYs patient-years, IRR incidence rate ratio, CI confidence interval, CVD cardiovascular disease
  2. aAdjusted by age and sex
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