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Table 2 Incidence rate ratios of cardiovascular disease

From: Risk for cardiovascular disease in Japanese patients with rheumatoid arthritis: a large-scale epidemiological study using a healthcare database

  RA patients (N = 8658) OA patients (N = 32,202) RA versus OA
Events PYs at risk Events PYs at risk Crude IRR (95 % CI) Adjusted IRRa (95 % CI)
CVD (total) 673 10,946 1633 43,304 1.63 (1.49–1.78) 2.12 (1.93–2.32)
 Ischemic heart disease 260 11,280 586 44,091 1.73 (1.50–2.01) 2.16 (1.86–2.50)
  Myocardial infarction 53 11,481 71 44,574 2.90 (2.03–4.14) 3.62 (2.52–5.18)
  Angina pectoris 224 11,319 528 44,138 1.65 (1.41–1.93) 2.05 (1.75–2.40)
 Heart failure 358 11,234 808 44,003 1.74 (1.53–1.97) 2.34 (2.07–2.65)
 Stroke 177 11,396 513 44,286 1.34 (1.13–1.59) 1.68 (1.41–2.00)
  Cerebral infarction 136 11,433 431 44,327 1.22 (1.01–1.48) 1.56 (1.29–1.90)
  Intracerebral hemorrhage 32 11,506 77 44,599 1.61 (1.07–2.43) 1.85 (1.22–2.81)
  Subarachnoid hemorrhage 15 11,517 15 44,626 3.87 (1.89–7.93) 4.45 (2.13–9.26)
  1. RA rheumatoid arthritis, OA osteoarthritis, PYs patient-years, IRR incidence rate ratio, CI confidence interval, CVD cardiovascular disease
  2. aAdjusted by age and sex