Fig. 2
H2S improves pathological changes of skin tissues in BLM-induced mice (×200). a–j HE stain; k–o Masson stain. a–e 7-day group; f–o 42-day group; a, f, k In the control group, the skin tissues had proper thickness and clear structure; b, g, l In the 7-day and 42-day model group, skin tissues points exhibited significant thickening of the dermis and disordered structure with increasing model establishment time; c, h, m and d, i, n In the low and high dose treatment group, the skin tissues exhibited a clear structure, the dermis became thinner, the lipid layer thickened, inflammatory cell filtration and collagen deposition significantly decreased compared to the model group; e, j, o Repeated injections of NaHS had little effect compared with the control group