Table 3 Cox-regression of independent variables to overall survival

Treatment

<0.001***

<0.001***

 Conservative treatment

1

–

1

–

TAE alone

0.04 (0.02–0.08)

<0.001***

0.05 (0.02–0.17)

<0.001***

 Staged surgery

0.03 (0.01–0.06)

<0.001***

0.02 (0.00–0.09)

<0.001***

 Emergency surgery

0.10 (0.05–0.20)

<0.001***

0.13 (0.03–0.50)

0.003**

Age (years)

1.04 (1.01–1.07)

0.019*

0.98 (0.93–1.04)

0.595

Gender (male)

1.24 (0.79–1.95)

0.353

0.37 (0.17–0.81)

0.012*

Etiology

0.028*

<0.001*

 HBV

1

–

1

–

 HCV

1.30 (0.75–2.23)

0.349

0.97 (0.43–2.19)

0.936

 Others

0.36 (0.16–0.82)

0.015*

0.07 (0.02–0.27)

<0.001***

Liver cirrhosis (yes)

7.25 (3.17–16.58)

<0.001***

4.73 (1.76–12.73)

0.002**

Child-Pugh stage

<0.001***

<0.001***

 A

1

–

1

–

 B

3.52 (2.28–5.44)

<0.001***

5.75 (2.86–11.54)

<0.001***

 C

15.54 (9.64–25.05)

<0.001***

16.09 (5.43–47.65)

<0.001***

Hemoglobin (g/L)

0.96 (0.94–0.98)

<0.001***

0.92 (0.87–0.98)

0.006**

Platelet (×10⁹/L)

1.00 (0.99–1.00)

0.422

0.99 (0.97–1.00)

0.057

INR

4.13 (2.97–5.73)

<0.001***

1.51 (0.87–2.63)

0.144

Albumin (g/L)

0.88 (0.84–0.92)

<0.001***

1.03 (0.94–1.13)

0.528

Total bilirubin (mmol/L)

1.07 (1.06–1.09)

<0.001***

1.02 (0.99–1.05)

0.132

ALT (IU/L)

1.00 (1.00–1.01)

<0.001***

1.00 (1.00–1.00)

0.381

Creatinine (mg/dL)

0.48 (0.20–1.14)

0.097

0.15 (0.02–0.99)

0.049*

AFP (µg/L)

1.00 (1.00–1.00)

0.019*

1.00 (1.00–1.00)

0.012*

Size of lesions (cm)

0.98 (0.91–1.06)

0.662

0.80 (0.68–0.93)

0.004**

Multiple tumors (yes)

1.34 (0.95–1.89)

0.094

0.25 (0.09–0.73)

0.011*

Portal vein (yes)

1.13 (0.80–1.61)

0.486

8.63 (2.79–26.66)

<0.001***

Modified UICC stage

0.002**

0.008**

 2

1

–

1

–

 3

1.13 (0.65–1.97)

0.657

5.20 (1.89–14.32)

0.001**

 4A

1.56 (0.92–2.64)

0.098

2.10 (0.75–5.86)

0.157

 4B

4.38 (1.92–10.02)

<0.001***

2.98 (0.65–13.55)

0.159

Morphology of lesions

<0.001***

0.247

 Nodular

1

–

1

–

 Infiltrative

3.29 (1.85–5.83)

<0.001***

1.19 (0.61–2.34)

0.604

 Pedunculated

2.14 (1.27–3.62)

0.004**

0.87 (0.48–1.58)

0.657

 Cirrhotomimetic

16.79 (7.02–40.18)

<0.001***

1.87 (0.65–5.38)

0.246