|
Variables
|
Estimated HR (95 % CI)
|
P
|
Adjusted HR (95 % CI)
|
P
|
|---|
|
Treatment
| |
<0.001***
| |
<0.001***
|
|
Conservative treatment
|
1
|
–
|
1
|
–
|
|
TAE alone
|
0.04 (0.02–0.08)
|
<0.001***
|
0.05 (0.02–0.17)
|
<0.001***
|
|
Staged surgery
|
0.03 (0.01–0.06)
|
<0.001***
|
0.02 (0.00–0.09)
|
<0.001***
|
|
Emergency surgery
|
0.10 (0.05–0.20)
|
<0.001***
|
0.13 (0.03–0.50)
|
0.003**
|
|
Age (years)
|
1.04 (1.01–1.07)
|
0.019*
|
0.98 (0.93–1.04)
|
0.595
|
|
Gender (male)
|
1.24 (0.79–1.95)
|
0.353
|
0.37 (0.17–0.81)
|
0.012*
|
|
Etiology
| |
0.028*
| |
<0.001*
|
|
HBV
|
1
|
–
|
1
|
–
|
|
HCV
|
1.30 (0.75–2.23)
|
0.349
|
0.97 (0.43–2.19)
|
0.936
|
|
Others
|
0.36 (0.16–0.82)
|
0.015*
|
0.07 (0.02–0.27)
|
<0.001***
|
|
Liver cirrhosis (yes)
|
7.25 (3.17–16.58)
|
<0.001***
|
4.73 (1.76–12.73)
|
0.002**
|
|
Child-Pugh stage
| |
<0.001***
| |
<0.001***
|
|
A
|
1
|
–
|
1
|
–
|
|
B
|
3.52 (2.28–5.44)
|
<0.001***
|
5.75 (2.86–11.54)
|
<0.001***
|
|
C
|
15.54 (9.64–25.05)
|
<0.001***
|
16.09 (5.43–47.65)
|
<0.001***
|
|
Hemoglobin (g/L)
|
0.96 (0.94–0.98)
|
<0.001***
|
0.92 (0.87–0.98)
|
0.006**
|
|
Platelet (×109/L)
|
1.00 (0.99–1.00)
|
0.422
|
0.99 (0.97–1.00)
|
0.057
|
|
INR
|
4.13 (2.97–5.73)
|
<0.001***
|
1.51 (0.87–2.63)
|
0.144
|
|
Albumin (g/L)
|
0.88 (0.84–0.92)
|
<0.001***
|
1.03 (0.94–1.13)
|
0.528
|
|
Total bilirubin (mmol/L)
|
1.07 (1.06–1.09)
|
<0.001***
|
1.02 (0.99–1.05)
|
0.132
|
|
ALT (IU/L)
|
1.00 (1.00–1.01)
|
<0.001***
|
1.00 (1.00–1.00)
|
0.381
|
|
Creatinine (mg/dL)
|
0.48 (0.20–1.14)
|
0.097
|
0.15 (0.02–0.99)
|
0.049*
|
|
AFP (µg/L)
|
1.00 (1.00–1.00)
|
0.019*
|
1.00 (1.00–1.00)
|
0.012*
|
|
Size of lesions (cm)
|
0.98 (0.91–1.06)
|
0.662
|
0.80 (0.68–0.93)
|
0.004**
|
|
Multiple tumors (yes)
|
1.34 (0.95–1.89)
|
0.094
|
0.25 (0.09–0.73)
|
0.011*
|
|
Portal vein (yes)
|
1.13 (0.80–1.61)
|
0.486
|
8.63 (2.79–26.66)
|
<0.001***
|
|
Modified UICC stage
| |
0.002**
| |
0.008**
|
|
2
|
1
|
–
|
1
|
–
|
|
3
|
1.13 (0.65–1.97)
|
0.657
|
5.20 (1.89–14.32)
|
0.001**
|
|
4A
|
1.56 (0.92–2.64)
|
0.098
|
2.10 (0.75–5.86)
|
0.157
|
|
4B
|
4.38 (1.92–10.02)
|
<0.001***
|
2.98 (0.65–13.55)
|
0.159
|
|
Morphology of lesions
| |
<0.001***
| |
0.247
|
|
Nodular
|
1
|
–
|
1
|
–
|
|
Infiltrative
|
3.29 (1.85–5.83)
|
<0.001***
|
1.19 (0.61–2.34)
|
0.604
|
|
Pedunculated
|
2.14 (1.27–3.62)
|
0.004**
|
0.87 (0.48–1.58)
|
0.657
|
|
Cirrhotomimetic
|
16.79 (7.02–40.18)
|
<0.001***
|
1.87 (0.65–5.38)
|
0.246
|
-
AFP α-fetoprotein, ALT alanine aminotransferase, HBV hepatitis B virus, HCV hepatitis C virus, INR international normalized ratio, UICC Union for International Cancer Control, HR hazard ratio, CI confidence interval
- * P < 0.05; ** P < 0.01; *** P < 0.001
