Fig. 2
From: In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon
Docking results for IMiDs. Eleven cereblon structures were classified into type A (PDB ID: 4CI1, 4V2Y, 4CI2, 4TZ4, 4V30, 4CI3, 4V2Z, and 4V31) and type B (PDB ID: 4TZC, 4TZU, and 3WX2). The average docking scores for IMiDs using type A (a) and type B (b) are shown. c Structural differences between type A (PDB ID: 4CI1) and type B (PDB ID: 3WX2) cereblon. β10–β11 hairpin of type A and type B cereblon structures are shown in magenta and green, respectively. The three tryptophan residues of the aromatic cage (W380, W386, and W400) of cereblon and (S)-enantiomer of thalidomide [(S)-thalidomide] are shown in orange and magenta, respectively. Thalidomide, lenalidomide, and pomalidomide are described in ‘thal’, ‘len’, ‘pom’ for short, respectively