Fig. 1
From: In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon
Structures of IMiDs and cereblon. a Structures of thalidomide, lenalidomide, and pomalidomide. b Schematic representation of enantiomeric selectivity for IMiDs. The NTD, HBD, and CBD domains of cereblon are shown in green, blue, and magenta, respectively. c Binding mode of IMiDs to cereblon. The CBD domain of the protein is shown in magenta, and the three tryptophans of the aromatic cage (W380, W386, and W400) and (S)-enantiomer of thalidomide [(S)-thalidomide] are shown in orange and green, respectively (PDB ID: 4CI1). Thalidomide, lenalidomide, and pomalidomide are described in ‘thal’, ‘len’, ‘pom’ for short, respectively