Diffusion tensor studies and voxel-based morphometry of the temporal lobe to determine the cognitive prognosis in cases of Alzheimer’s disease and mild cognitive impairment: Do white matter changes precede gray matter changes?

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Table 2 Correlation among the MMSE score, the z-score of the parahippocampal gyrus, diffusion tensor parameters (FA, ADC) of the uncinate fascicles on both sides compared with those of the next periods

	MMSE	z-score	R-FA	R-ADC	L-FA	L-ADC	Next MMSE	Next z-score	Next R-FA	Next R-ADC	Next L-FA	Next L-ADC
MMSE		−0.42	0.40	−0.38	0.49	−0.45	0.87	−0.47	0.29	−0.40	0.28	−0.39
z-score	P < 0.01		−0.04	0.35	0.09	0.34	−0.49	0.88	−0.08	0.27	−0.03	0.16
R-FA	P < 0.01	NS		−0.49	0.67	−0.36	0.46	−0.05	0.56	−0.35	0.48	−0.33
R-ADC	P < 0.01	P < 0.05	P < 0.001		−0.25	0.74	−0.37	0.46	−0.33	0.76	−0.31	0.70
L-FA	P < 0.001	NS	P < 0.001	NS		−0.35	0.51	0.07	0.52	−0.28	0.55	−0.25
L-ADC	P < 0.01	P < 0.05	P < 0.05	P < 0.001	P < 0.05		−0.50	0.39	−0.47	0.78	−0.31	0.81
Next MMSE	P < 0.001	P < 0.001	P < 0.01	P < 0.05	P < 0.001	P < 0.001		−0.52	0.32	−0.38	0.32	−0.42
Next z-score	P < 0.001	P < 0.001	NS	P < 0.01	NS	P < 0.01	P < 0.001		−0.05	0.37	−0.02	0.27
Next R-FA	NS	NS	P < 0.001	P < 0.05	P < 0.001	P < 0.01	P < 0.05	NS		−0.51	0.67	−0.46
Next R-ADC	P < 0.01	NS	P < 0.05	P < 0.001	NS	P < 0.001	P < 0.01	P < 0.05	P < 0.001		−0.31	0.78
Next L-FA	NS	NS	P < 0.001	P < 0.05	P < 0.001	P < 0.05	P < 0.05	NS	P < 0.001	P < 0.05		−0.39
Next L-ADC	P < 0.01	NS	P < 0.05	P < 0.001	NS	P < 0.001	P < 0.01	NS	P < 0.01	P < 0.001	P < 0.01