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Table 2 Correlations between P-p38 MAPK expression and clinicopathologic parameters

From: Phosphorylated-p38 mitogen-activated protein kinase expression is associated with clinical factors in invasive breast cancer

Factors

P-p38 MAPK of cytoplasm

Negative

Positive

R

P

Luminal A/B (n = 197)

HER2-positive (n = 74)

Triple negative (n = 84)

R

P

R

P

R

P

Median age (years)

 Median (range)

53 (30–81)

53 (31–81)

0.037

0.357

0.001

0.988

0.017

0.848

0.176

0.036

Menopause

 Yes

103

90

0.002

0.687

−0.039

0.558

−0.018

0.87

0.19

0.058

 No

91

71

        

Depth of invasion

 T1

73

57

0

0.999

0.042

0.517

−0.063

0.543

−0.03

0.759

 T2/T3/T4

121

104

        

Regional lymph node metastasis

 Negative (N0)

60

93

0.016

0.72

0.027

0.662

0.026

0.795

−0.024

0.807

 Positive (N1/N2/N3)

134

68

        

Stage

 I

60

49

−0.077

0.098

−0.046

0.463

−0.158

0.127

−0.088

0.365

 II/III

134

112

        

Histologic grade

 I

13

10

−0.034

0.474

0.003

0.961

−0.204

0.057

−0.067

0.5

 II/III

181

151

        

Histologic type

 Ductal

182

148

0.009

0.85

−0.041

0.533

0.147

0.173

−0.011

0.912

 Lobular

12

13

        

ER

 Negative

86

77

0.013

0.775

0.148

0.025

 Positive

108

84

        

PR

 Negative

122

93

0.083

0.078

0.22

0.001

 Positive

72

68

        

Her2

 Negative

108

93

0.015

0.745

0.029

0.646

0.31

0.003

 Positive

86

68

        

P-p38 MAPK of nucleus

 Negative

163

9

0.772

0.000

0.784

0.000

0.812

0.000

0.717

0.000

 Positive

31

152

        

Factors

P-p38 MAPK of nucleus

Negative

Positive

R

P

Luminal A/B (n = 197)

HER2-positive (n = 74)

Triple negative (n = 84)

R

P

R

P

R

P

Median age (years)

 Median (range)

53 (30–59)

53 (31–81)

0.028

0.479

0.012

0.817

0.037

0.684

0.099

0.234

Menopause

 Yes

95

98

−0.019

0.691

−0.043

0.507

0.005

0.965

0.042

0.671

 No

77

85

        

Depth of invasion

 T1

60

70

−0.026

0.586

0.005

0.935

−0.042

0.684

−0.059

0.542

 T2/T3/T4

112

113

        

Regional lymph node metastasis

 Negative (N0)

74

79

−0.019

0.68

−0.033

0.584

0.045

0.653

−0.031

0.747

 Positive (N1/N2/N3)

98

104

        

Stage

 I

49

60

−0.087

0.061

−0.068

0.272

−0.108

0.295

−0.129

0.182

 II/III

123

123

        

Histologic grade

 I

10

13

−0.092

0.05

−0.052

0.408

−0.135

0.21

−0.143

0.148

 II/III

162

170

        

Histologic type

 Ductal

160

170

−0.005

0.924

−0.063

0.333

0.212

0.05

−0.073

0.462

 Lobular

12

13

        

ER

 Negative

82

81

0.07

0.127

0.122

0.053

 Positive

90

102

        

PR

 Negative

116

99

0.171

0.000

0.225

0.000

 Positive

56

84

        

Her2

 Negative

  

−0.006

0.894

−0.018

0.771

0.257

0.013

 Positive

82

72

        

P-p38 MAPK of nucleus

 Negative

  

0.784

0.000

0.812

0.003

0.727

0.000

 Positive