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Table 2 Correlations between P-p38 MAPK expression and clinicopathologic parameters

From: Phosphorylated-p38 mitogen-activated protein kinase expression is associated with clinical factors in invasive breast cancer

Factors P-p38 MAPK of cytoplasm
Negative Positive R P Luminal A/B (n = 197) HER2-positive (n = 74) Triple negative (n = 84)
R P R P R P
Median age (years)
 Median (range) 53 (30–81) 53 (31–81) 0.037 0.357 0.001 0.988 0.017 0.848 0.176 0.036
Menopause
 Yes 103 90 0.002 0.687 −0.039 0.558 −0.018 0.87 0.19 0.058
 No 91 71         
Depth of invasion
 T1 73 57 0 0.999 0.042 0.517 −0.063 0.543 −0.03 0.759
 T2/T3/T4 121 104         
Regional lymph node metastasis
 Negative (N0) 60 93 0.016 0.72 0.027 0.662 0.026 0.795 −0.024 0.807
 Positive (N1/N2/N3) 134 68         
Stage
 I 60 49 −0.077 0.098 −0.046 0.463 −0.158 0.127 −0.088 0.365
 II/III 134 112         
Histologic grade
 I 13 10 −0.034 0.474 0.003 0.961 −0.204 0.057 −0.067 0.5
 II/III 181 151         
Histologic type
 Ductal 182 148 0.009 0.85 −0.041 0.533 0.147 0.173 −0.011 0.912
 Lobular 12 13         
ER
 Negative 86 77 0.013 0.775 0.148 0.025
 Positive 108 84         
PR
 Negative 122 93 0.083 0.078 0.22 0.001
 Positive 72 68         
Her2
 Negative 108 93 0.015 0.745 0.029 0.646 0.31 0.003
 Positive 86 68         
P-p38 MAPK of nucleus
 Negative 163 9 0.772 0.000 0.784 0.000 0.812 0.000 0.717 0.000
 Positive 31 152         
Factors P-p38 MAPK of nucleus
Negative Positive R P Luminal A/B (n = 197) HER2-positive (n = 74) Triple negative (n = 84)
R P R P R P
Median age (years)
 Median (range) 53 (30–59) 53 (31–81) 0.028 0.479 0.012 0.817 0.037 0.684 0.099 0.234
Menopause
 Yes 95 98 −0.019 0.691 −0.043 0.507 0.005 0.965 0.042 0.671
 No 77 85         
Depth of invasion
 T1 60 70 −0.026 0.586 0.005 0.935 −0.042 0.684 −0.059 0.542
 T2/T3/T4 112 113         
Regional lymph node metastasis
 Negative (N0) 74 79 −0.019 0.68 −0.033 0.584 0.045 0.653 −0.031 0.747
 Positive (N1/N2/N3) 98 104         
Stage
 I 49 60 −0.087 0.061 −0.068 0.272 −0.108 0.295 −0.129 0.182
 II/III 123 123         
Histologic grade
 I 10 13 −0.092 0.05 −0.052 0.408 −0.135 0.21 −0.143 0.148
 II/III 162 170         
Histologic type
 Ductal 160 170 −0.005 0.924 −0.063 0.333 0.212 0.05 −0.073 0.462
 Lobular 12 13         
ER
 Negative 82 81 0.07 0.127 0.122 0.053
 Positive 90 102         
PR
 Negative 116 99 0.171 0.000 0.225 0.000
 Positive 56 84         
Her2
 Negative    −0.006 0.894 −0.018 0.771 0.257 0.013
 Positive 82 72         
P-p38 MAPK of nucleus
 Negative    0.784 0.000 0.812 0.003 0.727 0.000
 Positive