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Table 2 Minimal inhibitory concentrations (MICs) of the studied compounds against the tested bacterial species

From: Antibacterial activities and structure–activity relationships of a panel of 48 compounds from Kenyan plants against multidrug resistant phenotypes

Compounds Bacteria and MIC values in absence and presence of PAβN (in µg/mL) (with 30 mg/mL PAβNa)
E. coli K. pneumoniae
ATTC 8739 ATCC 10536 AG 100 AG 102 AG 100ATet ATCC 11296 KP 55 KP63
Anthraquinones
 1  
 2 128 (2) 16 (4) 32 (<2) 128 (2)
 3 256
 4 256
Naphthoquinones
 5 NT NT NT 2 (2) 4 (<0.5) NT 2 (2) 4 (2)
Benzoquinones
 6 128 258 (128) 128 (64) 258 (128) 64 128 (128) 256 (128)
 7 256 64 (32) 64 (16) 64 (32) 128 64 (64) 64 (32)
 8 16 64 32 (16) 16 (8) 32 (32) 32 (32) 32 (16)
 9 32 4 (4) 4 (<2) 8 (<2) 32 8 (4) 4 (4)
 10 32 (8) 32 (16) 64 (64) 256 32 (32) 32 (16)
 11 16 32 16
 12
 13 64 16 (<2) 8 (<2) 16 (<2) 128 8 (<2) 8 (4)
 14
 15
 16 64
 17
 18 16 16 256 64 (64) 64 (32) 16 32 (32) 64 (32)
Flavonoids chalcones
 19
 20
 21
 22
 23
 24
Flavones
 25
 26
 27
 28 256
 29
 30
 31
 32
 33
 34 128 128 128
Flavanones
 35
 36
 37
Diterpenoids clerodane type
 38
 39
 40
 41 256 128 256
Kaurane type
 42
 43
 44
 45
 46 256
 47 256 256
 48
CHL 4 16 8 4 32 16 8 32
Compounds Bacteria and MIC values in absence and presence of PAβN (in µg/mL) (with 30 mg/mL PAβNa)
P. aeruginosa   P. stuartii   E. aerogenes     
PA01 PA124 ATCC 29916 −E16 ATCC 13048 EA-CM64 EA3 EA27 EA289
Anthraquinones
 1
 2 128
 3
 4
Naphthoquinones
 5 NT NT 64 64
Benzoquinones
 6 32 128 (128) 64 128 128 (32) 128 (128) 128 (32)  
 7 32 64 (32) 128 32 64 (16) 64 (32) 64 (32)  
 8 16 64 (16) 32 64 32 (8) 32 (32) 128 32 (16)  
 9 16 16 (4) 32 256 4 (4) 64 (4) 8 (<2)  
 10 16 64 (32) 256 8 64 (32) 64 (8)  
 11  
 12  
 13 32 16 (4) 128 128 8 (<2) 16 (8) 8 (<2)  
 14  
 15 256  
 16  
 17  
 18 256 16 16 32 16-  
Flavonoids chalcones
 19
 20 256
 21 128
 22
 23 256
 24
Flavones
 25
 26
 27
 28
 29
 30
 31
 32
 33
 34 128 128
Flavanones
 35
 36
 37
Diterpenoids clerodane type
 38
 39
 40 256
 41 128 128
Kaurane type
 42
 43
 44 256
 45
 46
 47 256
 48 64
CHL 8 128 16 32 4 256 32 64 128
Compounds Bacteria and MIC values in absence and presence of PAβN (in µg/mL) (with 30 mg/mL PAβNa)
S. aureus          
ATCC 1026 SA3 SA4 SA11 SA12 ATCC 1026 MRSA3 MRSA4 MRSA6 MRSA8
Anthraquinones
 1
 2 4 (2) 4 (0.5) 4 (1)
 3
 4
Naphthoquinones
 5 NT NT NT NT NT NT 64 2 (1) 2 (<0.5) 2 (<0.5)
Benzoquinones
 6 256 64 256 64 128 256
 7 64 256 64 128
 8 32 256 16 32
 9 4 128 16 16
 10 4 256 64 16
 11 4 32 64
 12 128 64
 13 4 128 16
 14
 15
 16
 17 32 16 64
 18 64 (64) 64 (64) 32 (32)
Flavonoids Chalcones
 19 64 128
 20
 21 128 16 32 64
 22
 23
 24 128
Flavones
 25
 26
 27 32
 28
 29
 30
 31
 32
 33 32
 34 128 256
Flavanones
 35
 36
 37
Diterpenoids clerodane type
 38
 39 128
 40
 41 64 128
Kaurane type
 42
 43
 44
 45
 46
 47
 48
CHL 128 4 8 4 8 128 8 64 32
  1. NT not tested because the sample was insufficient, – sample not active up to 256 mg/L, CHL chloramphenicol
  2. aThe MIC of PAβN was 64 μg/mL for AG100A and >256 mg/L for other E. coli, E. aerogenes, K. pneumoniae and P. aerogenes strains