Table 2 Minimal inhibitory concentrations (MICs) of the studied compounds against the tested bacterial species
Compounds | Bacteria and MIC values in absence and presence of PAβN (in µg/mL) (with 30 mg/mL PAβNa) | |||||||
|---|---|---|---|---|---|---|---|---|
E. coli | K. pneumoniae | |||||||
ATTC 8739 | ATCC 10536 | AG 100 | AG 102 | AG 100ATet | ATCC 11296 | KP 55 | KP63 | |
Anthraquinones | ||||||||
1 | – | – | – | – | – | – | – | |
2 | – | – | – | 128 (2) | 16 (4) | – | 32 (<2) | 128 (2) |
3 | 256 | – | – | – | – | – | – | – |
4 | 256 | – | – | – | – | – | – | – |
Naphthoquinones | ||||||||
5 | NT | NT | NT | 2 (2) | 4 (<0.5) | NT | 2 (2) | 4 (2) |
Benzoquinones | ||||||||
6 | 128 | – | 258 (128) | 128 (64) | 258 (128) | 64 | 128 (128) | 256 (128) |
7 | 256 | – | 64 (32) | 64 (16) | 64 (32) | 128 | 64 (64) | 64 (32) |
8 | 16 | 64 | 32 (16) | 16 (8) | 32 (32) | – | 32 (32) | 32 (16) |
9 | 32 | – | 4 (4) | 4 (<2) | 8 (<2) | 32 | 8 (4) | 4 (4) |
10 | – | – | 32 (8) | 32 (16) | 64 (64) | 256 | 32 (32) | 32 (16) |
11 | – | – | – | – | 16 | – | 32 | 16 |
12 | – | – | – | – | – | – | – | – |
13 | 64 | – | 16 (<2) | 8 (<2) | 16 (<2) | 128 | 8 (<2) | 8 (4) |
14 | – | – | – | – | – | – | – | – |
15 | – | – | – | – | – | – | – | – |
16 | – | – | – | – | – | – | 64 | – |
17 | – | – | – | – | – | – | – | – |
18 | 16 | 16 | 256 | 64 (64) | 64 (32) | 16 | 32 (32) | 64 (32) |
Flavonoids chalcones | ||||||||
19 | – | – | – | – | – | – | – | – |
20 | – | – | – | – | – | – | – | – |
21 | – | – | – | – | – | – | – | – |
22 | – | – | – | – | – | – | – | – |
23 | – | – | – | – | – | – | – | – |
24 | – | – | – | – | – | – | – | – |
Flavones | ||||||||
25 | – | – | – | – | – | – | – | – |
26 | – | – | – | – | – | – | – | – |
27 | – | – | – | – | – | – | – | – |
28 | 256 | – | – | – | – | – | – | – |
29 | – | – | – | – | – | – | – | – |
30 | – | – | – | – | – | – | – | – |
31 | – | – | – | – | – | – | – | – |
32 | – | – | – | – | – | – | – | – |
33 | – | – | – | – | – | – | – | – |
34 | 128 | – | – | – | – | 128 | 128 | – |
Flavanones | ||||||||
35 | – | – | – | – | – | – | – | – |
36 | – | – | – | – | – | – | – | – |
37 | – | – | – | – | – | – | – | – |
Diterpenoids clerodane type | ||||||||
38 | – | – | – | – | – | – | – | – |
39 | – | – | – | – | – | – | – | – |
40 | – | – | – | – | – | – | – | – |
41 | 256 | – | – | – | – | – | 128 | 256 |
Kaurane type | ||||||||
42 | – | – | – | – | – | – | – | – |
43 | – | – | – | – | – | – | – | – |
44 | – | – | – | – | – | – | – | – |
45 | – | – | – | – | – | – | – | – |
46 | – | – | – | – | – | 256 | – | – |
47 | 256 | – | – | – | – | – | 256 | – |
48 | – | – | – | – | – | – | – | – |
CHL | 4 | 16 | 8 | 4 | 32 | 16 | 8 | 32 |
Compounds | Bacteria and MIC values in absence and presence of PAβN (in µg/mL) (with 30 mg/mL PAβNa) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
P. aeruginosa | P. stuartii | E. aerogenes | |||||||
PA01 | PA124 | ATCC 29916 | −E16 | ATCC 13048 | EA-CM64 | EA3 | EA27 | EA289 | |
Anthraquinones | |||||||||
1 | – | – | – | – | – | – | – | – | – |
2 | – | – | – | – | – | – | – | – | 128 |
3 | – | – | – | – | – | – | – | – | – |
4 | – | – | – | – | – | – | – | – | – |
Naphthoquinones | |||||||||
5 | – | – | – | – | – | NT | NT | 64 | 64 |
Benzoquinones | |||||||||
6 | 32 | 128 (128) | 64 | 128 | 128 (32) | 128 (128) | – | 128 (32) | |
7 | 32 | 64 (32) | 128 | 32 | 64 (16) | 64 (32) | – | 64 (32) | |
8 | 16 | 64 (16) | 32 | 64 | 32 (8) | 32 (32) | 128 | 32 (16) | |
9 | 16 | 16 (4) | 32 | 256 | 4 (4) | 64 (4) | – | 8 (<2) | |
10 | 16 | 64 (32) | – | 256 | 8 | 64 (32) | – | 64 (8) | |
11 | – | – | – | – | – | – | – | – | |
12 | – | – | – | – | – | – | – | – | |
13 | 32 | 16 (4) | 128 | 128 | 8 (<2) | 16 (8) | – | 8 (<2) | |
14 | – | – | – | – | – | – | – | – | |
15 | – | – | – | – | 256 | – | – | – | |
16 | – | – | – | – | – | – | – | – | |
17 | – | – | – | – | – | – | – | – | |
18 | – | 256 | 16 | 16 | – | – | 32 | 16- | |
Flavonoids chalcones | |||||||||
19 | – | – | – | – | – | – | – | – | – |
20 | – | – | – | – | 256 | – | – | – | – |
21 | – | – | – | – | – | – | – | – | 128 |
22 | – | – | – | – | – | – | – | – | – |
23 | – | – | – | – | 256 | – | – | – | – |
24 | – | – | – | – | – | – | – | – | – |
Flavones | |||||||||
25 | – | – | – | – | – | – | – | – | – |
26 | – | – | – | – | – | – | – | – | – |
27 | – | – | – | – | – | – | – | – | – |
28 | – | – | – | – | – | – | – | – | – |
29 | – | – | – | – | – | – | – | – | – |
30 | – | – | – | – | – | – | – | – | – |
31 | – | – | – | – | – | – | – | – | – |
32 | – | – | – | – | – | – | – | – | – |
33 | – | – | – | – | – | – | – | – | – |
34 | 128 | – | – | – | 128 | – | – | – | – |
Flavanones | |||||||||
35 | – | – | – | – | – | – | – | – | – |
36 | – | – | – | – | – | – | – | – | – |
37 | – | – | – | – | – | – | – | – | – |
Diterpenoids clerodane type | |||||||||
38 | – | – | – | – | – | – | – | – | – |
39 | – | – | – | – | – | – | – | – | – |
40 | – | – | – | – | 256 | – | – | – | – |
41 | 128 | – | – | – | 128 | – | – | – | – |
Kaurane type | |||||||||
42 | – | – | – | – | – | – | – | – | – |
43 | – | – | – | – | – | – | – | – | – |
44 | – | – | – | – | 256 | – | – | – | – |
45 | – | – | – | – | – | – | – | – | – |
46 | – | – | – | – | – | – | – | – | – |
47 | – | – | – | – | 256 | – | – | – | – |
48 | – | – | – | – | 64 | – | – | – | – |
CHL | 8 | 128 | 16 | 32 | 4 | 256 | 32 | 64 | 128 |
Compounds | Bacteria and MIC values in absence and presence of PAβN (in µg/mL) (with 30 mg/mL PAβNa) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
S. aureus | ||||||||||
ATCC 1026 | SA3 | SA4 | SA11 | SA12 | ATCC 1026 | MRSA3 | MRSA4 | MRSA6 | MRSA8 | |
Anthraquinones | ||||||||||
1 | – | – | – | – | – | – | – | – | – | – |
2 | – | – | – | – | – | – | – | 4 (2) | 4 (0.5) | 4 (1) |
3 | – | – | – | – | – | – | – | – | – | – |
4 | – | – | – | – | – | – | – | – | – | – |
Naphthoquinones | ||||||||||
5 | NT | NT | NT | NT | NT | NT | 64 | 2 (1) | 2 (<0.5) | 2 (<0.5) |
Benzoquinones | ||||||||||
6 | 256 | 64 | 256 | 64 | 128 | 256 | – | – | – | – |
7 | – | 64 | 256 | 64 | 128 | – | – | – | – | – |
8 | – | 32 | 256 | 16 | 32 | – | – | – | – | – |
9 | – | 4 | 128 | 16 | 16 | – | – | – | – | – |
10 | – | 4 | 256 | 64 | 16 | – | – | – | – | – |
11 | – | – | – | – | – | – | – | 4 | 32 | 64 |
12 | – | – | – | – | – | – | – | 128 | – | 64 |
13 | – | 4 | – | 128 | 16 | – | – | – | – | – |
14 | – | – | – | – | – | – | – | – | – | – |
15 | – | – | – | – | – | – | – | – | – | – |
16 | – | – | – | – | – | – | – | – | – | – |
17 | – | – | – | – | – | – | – | 32 | 16 | 64 |
18 | – | – | – | – | – | – | – | 64 (64) | 64 (64) | 32 (32) |
Flavonoids Chalcones | ||||||||||
19 | – | – | – | – | – | – | – | 64 | 128 | – |
20 | – | – | – | – | – | – | – | – | – | – |
21 | – | – | – | – | – | – | 128 | 16 | 32 | 64 |
22 | – | – | – | – | – | – | – | – | – | – |
23 | – | – | – | – | – | – | – | – | – | – |
24 | – | – | – | – | – | – | – | 128 | – | – |
Flavones | ||||||||||
25 | – | – | – | – | – | – | – | – | – | – |
26 | – | – | – | – | – | – | – | – | – | – |
27 | – | – | – | – | – | – | – | – | – | 32 |
28 | – | – | – | – | – | – | – | – | – | – |
29 | – | – | – | – | – | – | – | – | – | – |
30 | – | – | – | – | – | – | – | – | – | – |
31 | – | – | – | – | – | – | – | – | – | – |
32 | – | – | – | – | – | – | – | – | – | – |
33 | – | – | – | – | – | – | – | 32 | – | – |
34 | – | – | – | 128 | 256 | – | – | – | – | – |
Flavanones | ||||||||||
35 | – | – | – | – | – | – | – | – | – | – |
36 | – | – | – | – | – | – | – | – | – | – |
37 | – | – | – | – | – | – | – | – | – | – |
Diterpenoids clerodane type | ||||||||||
38 | – | – | – | – | – | – | – | – | – | – |
39 | – | – | – | – | – | – | – | 128 | – | – |
40 | – | – | – | – | – | – | – | – | – | – |
41 | – | – | – | 64 | 128 | – | – | – | – | – |
Kaurane type | ||||||||||
42 | – | – | – | – | – | – | – | – | – | – |
43 | – | – | – | – | – | – | – | – | – | – |
44 | – | – | – | – | – | – | – | – | – | – |
45 | – | – | – | – | – | – | – | – | – | – |
46 | – | – | – | – | – | – | – | – | – | – |
47 | – | – | – | – | – | – | – | – | – | – |
48 | – | – | – | – | – | – | – | – | – | – |
CHL | 128 | 4 | 8 | 4 | 8 | 128 | – | 8 | 64 | 32 |