Table 2 Sample descriptive statistics and outcomes of simple logistic regression analyses examining relationships between buprenorphine and metabolite cord blood concentrations and neonate and maternal characteristics, and necessity (yes/no) of morphine replacement therapya (N = 19)
Parameter | Mean (SD) | Morphine replacement therapy necessity | |
|---|---|---|---|
OR (95 % CI) | Effect size | ||
Duration of NICU stay (days) | 6.6 (9.2) | NA | NA |
Duration of morphine therapy (days) | 5.1 (8.3) | NA | NA |
Gestational age (weeks) | 38.5 (1.4) | 1.88 (0.12–29.78) | 0.35 |
Birth weight (kg) | 2.9 (0.39) | 3.10 (0.23–42.65) | 0.63 |
Maternal daily buprenorphine dose (mg) | 11.2 (6.3) | 1.01 (0.87–1.18) | 0.01 |
Buprenorphine concentration (ng/ml) | 9.0 (6.7) | 0.97 (0.83–1.12) | 0.01 |
Norbuprenorphine concentration (ng/ml) | 13.8 (8.0) | 1.92 (0.86–4.16) | 0.36 |
Buprenorphine-glucuronide concentration (ng/ml) | 14.0 (8.2) | 0.46 (0.20–1.06) | 0.43 |
Norbuprenorphine-glucuronide concentration (ng/ml) | 23.3 (15.5) | 0.98 (0.92–1.04) | 0.01 |