Table 3 Association between reoperation and grouped genotypes of inflammatory mediators
From: Association of inflammatory gene polymorphisms with mechanical heart valve reoperation
Gene polymorphisms (minor allele frequency) | Patient number | p value | OR (95 % CI) | |
|---|---|---|---|---|
Number of heart valve operations | ||||
1 | ≥2 | |||
IL1B rs16944 (0.43) | ||||
AA, AG | 126 | 27 | 0.756 | 1 |
GG | 63 | 12 | 0.889 (0.422–1.871) | |
IL6 rs1800796 (0.27) | ||||
GG | 15 | 2 | 0.744 | 1 |
GC, CC | 172 | 37 | 1.613 (0.534–7.359) | |
IL10 rs1800871 (0.29) | ||||
AA, AG | 170 | 37 | 0.743 | 1 |
GG | 15 | 2 | 0.613 (0.134–2.794) | |
IL10 rs1800896 (0.07)a | ||||
TT, TC | 184 | 37 | 0.030 | |
CC | 0 | 2 | ||
IFNG rs2430561 (0.20) | ||||
AA | 154 | 31 | 0.574 | 1 |
AT, TT | 31 | 8 | 1.282 (0.538–3.053) | |
TNFA rs1800629 (0.04) | ||||
GG | 173 | 37 | 0.548 | 1 |
GA, AA | 16 | 2 | 0.584 (0.129–2.652) | |
TGFB1 rs1800470 (0.47) | ||||
GG, GA | 145 | 29 | 0.584 | 1 |
AA | 40 | 10 | 1.250 (0.562–2.780) | |
CRP rs1205 (0.40) | ||||
CC, CT | 129 | 15 | 0.001 | 1 |
TT | 60 | 23 | 3.297 (1.606–6.766) | |