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Table 4 Univariate Cox regression analyses of survival at base line

From: Quality of Life in Spanish advanced non-small-cell lung cancer patients: determinants of global QL and survival analyses

Explanatory variables

Unadjusteda

Adjustedb

HR (95 % CI)

p

HR (95 % CI)

p

Socio-demographic and clinical variables

 Age (continuous)

0.98 (0.95–1.01)

0.282

  

 Gender (male vs. female)

1.92 (0.66–5.56)

0.229

  

 Civil status (married vs. other status)

0.97 (0.29–3.20)

0.966

  

 Limiting comorbidity (yes vs. no)

1.13 (0.71–2.40)

0.386

  

 Chemotherapy protocol (carboplatin vs. cisplatin)

0.65 (0.32–1.13)

0.230

  

 Performance status (continuous)

0.95 (0.92–0.99)

0.018

0.59 (0.39–0.88)

0.010

QLQ-C30 areas

 Physicalc

0.83 (0.72–0.96)

0.011

0.81 (0.71–0.93)

0.004

 Rolec

0.86 (0.77–0.96)

0.006

0.87 (0.77–0.99)

0.022

 Emotionalc

0.96 (0.87–1.11)

0.804

1.01 (0.88–1.17)

0.853

 Cognitivec

0.85 (0.73–0.99)

0.044

0.88 (0.73–1.06)

0.169

 Socialc

0.91 (0.82–1.01)

0.099

0.93 (0.82–1.06)

0.268

 Globalc

0.90 (0.76–1.06)

0.210

0.88 (0.73–1.07)

0.203

 Fatigued

1.25 (1.09–1.43)

0.002

1.25 (1.08–1.44)

0.003

 Nausead

1.08 (0.97–1.34)

0.490

0.93 (0.67–1.31)

0.697

 Paind

1.26 (1.20–1.44)

0.001

1.26 (1.09–1.45)

0.002

 Dyspnoead

1.03 (0.90–1.18)

0.620

1.04 (0.90–1.19)

0.602

 Sleep disturbanced

0.99 (0.92–1.08)

0.939

1.01 (0.92–1.11)

0.818

 Appetite lossd

1.14 (1.03–1.26)

0.008

1.13 (1.10–1.27)

0.029

 Constipationd

1.03 (0.95–1.13)

0.422

1.03 (0.94–1.14)

0.495

 Diarrhoead

1.01 (0.86–1.18)

0.930

1.04 (0.89–1.22)

0.607

 Financial impactd

1.19 (1.03–1.37)

0.019

1.16 (0.99–1.34)

0.600

QLQ-LC13 areas

 Coughingd

1.01 (0.91–1.14)

0.755

1.02 (0.91–1.15)

0.709

 Dyspnoead

1.17 (0.97–1.42)

0.104

1.14 (0.94–1.39)

0.191

 Haemoptysisd

1.37 (0.94–1.98)

0.099

1.39 (0.95–2.03)

0.090

 Sore mouthd

1.25 (1.05–1.49)

0.010

1.27 (1.06–1.52)

0.008

Dysphagiad

1.16 (0.94–1.43)

0.167

1.19 (0.97–1.47)

0.099

 Peripheral neuropathyd

1.04 (0.86–1.27)

0.655

1.04 (0.85–1.27)

0.702

 Hair lossd

1.08 (0.92–1.25)

0.355

1.07 (0.91–1.25)

0.434

 Chest paind

1.07 (0.89–1.29)

0.425

1.02 (0.85–1.23)

0.815

 Pain in arm or shoulderd

1.19 (1.01–1.40)

0.034

1.22 (1.03–1.45)

0.024

 Other pain sitesd

1.18 (1.03–1.33)

0.012

1.20 (1.06–1.36)

0.005

  1. HRs hazard ratios, CI confidence interval
  2. aUnadjusted: Univariate Cox proportional hazards models
  3. bAdjusted: Univariate Cox proportional hazards models adjusted for gender and age
  4. cThe scores range from 0 to 100, where a higher score represents a higher functional level
  5. dThe scores range from 0 to 100, where a higher score represents a greater degree of symptoms
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