Pooled bioequivalence study database from Turkey: characterization of adverse events and determination of split points based on Gini Index as a promising method

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Table 5 Results observed above/below split points for Cmax values in terms of ATC subgroups

Cmax	Number of adverse events		Number of subjects		Probabilities
ATC subgroups	Below split point	Above split point	Below split point	Above split point	Below split point	Above split point
Cardiovascular system	17	17	173	154	0.098	0.110
Antiinfectives for systemic use	11	14	162	249	0.068	0.055
Musculo-skeletal system	11	10	136	188	0.081	0.053
Alimentary tract and metabolism	27	66	109	241	0.248	0.274
Nervous system	70	67	249	188	0.281	0.356
Respiratory system	2	9	13	83	0.154	0.108
Genito-urinary system and sex hormones	3	27	12	35	0.25	0.771

Probabilities are calculated by number of adverse events below (above) the split point/number of subjects below (above) the split point, and higher probabilities given in italic font