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Table 5 Results observed above/below split points for Cmax values in terms of ATC subgroups

From: Pooled bioequivalence study database from Turkey: characterization of adverse events and determination of split points based on Gini Index as a promising method

Cmax Number of adverse events Number of subjects Probabilities
ATC subgroups Below split point Above split point Below split point Above split point Below split point Above split point
Cardiovascular system 17 17 173 154 0.098 0.110
Antiinfectives for systemic use 11 14 162 249 0.068 0.055
Musculo-skeletal system 11 10 136 188 0.081 0.053
Alimentary tract and metabolism 27 66 109 241 0.248 0.274
Nervous system 70 67 249 188 0.281 0.356
Respiratory system 2 9 13 83 0.154 0.108
Genito-urinary system and sex hormones 3 27 12 35 0.25 0.771
  1. Probabilities are calculated by number of adverse events below (above) the split point/number of subjects below (above) the split point, and higher probabilities given in italic font